Altered diastolic function and aortic stiffness in Alzheimer’s disease
Ali Nazmi Çalik,3 Kazim Serhan Özcan,4 Gülbün Yüksel,2 Baris Güngör,1 Emre Arugarslan,1 Figen Varlibas,2 Ahmet Ekmekci,1 Damirbek Osmonov,1 Mustafa Adem Tatlisu,1 Mehmet Karaca,1 Osman Bolca,1 Izzet Erdinler1 1Department of Cardiology...
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Dove Medical Press
2014
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oai:doaj.org-article:2b08e690bfa640a9b5b94edc9e4699db2021-12-02T02:44:20ZAltered diastolic function and aortic stiffness in Alzheimer’s disease1178-1998https://doaj.org/article/2b08e690bfa640a9b5b94edc9e4699db2014-07-01T00:00:00Zhttps://www.dovepress.com/altered-diastolic-function-and-aortic-stiffness-in-alzheimerrsquos-dis-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ali Nazmi Çalik,3 Kazim Serhan Özcan,4 Gülbün Yüksel,2 Baris Güngör,1 Emre Arugarslan,1 Figen Varlibas,2 Ahmet Ekmekci,1 Damirbek Osmonov,1 Mustafa Adem Tatlisu,1 Mehmet Karaca,1 Osman Bolca,1 Izzet Erdinler1 1Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey; 2Department of Neurology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey; 3Department of Cardiology, Yozgat State Hospital, Yozgat, Turkey; 4Department of Cardiology, Derince Training and Research Hospital, Kocaeli, Turkey Background: Alzheimer’s disease (AD) is closely linked to cardiovascular risk factors.Methods: Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and distensibility, on 29 patients with AD and 24 age-matched individuals with normal cognitive function.Results: The peak mitral flow velocity of the early rapid filling wave (E) was lower, and the peak velocity of the late filling wave caused by atrial contraction (A), deceleration time of peak E velocity, and isovolumetric relaxation time were higher in the AD group. The early myocardial peak (Ea) velocity was significantly lower in AD patients, whereas the late diastolic (Aa) velocity and E/Ea ratio were similar between the two groups. In Alzheimer patients, stiffness index and pressure-strain elastic modulus were higher, and distensibility was significantly lower in the AD group compared to the control. Interatrial electromechanical delay was significantly longer in the AD group.Conclusion: Our findings suggest that patients with AD are more likely to have diastolic dysfunction, higher atrial conduction times, and increased arterial stiffness compared to the controls of same sex and similar age. Keywords: diastolic dysfunction, atrial conduction timeA Letter to the Editor has been received and published for this article.Çalık ANÖzcan KSYüksel GGüngör BAruğarslan EVarlibas FEkmekci AOsmonov DTatlısu MAKaraca MBolca OErdinler IDove Medical PressarticleAlzheimer's DiseaseDiastolic dysfunctionAortic stiffnessatrial conduction timeGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1115-1121 (2014) |
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DOAJ |
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DOAJ |
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EN |
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Alzheimer's Disease Diastolic dysfunction Aortic stiffness atrial conduction time Geriatrics RC952-954.6 |
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Alzheimer's Disease Diastolic dysfunction Aortic stiffness atrial conduction time Geriatrics RC952-954.6 Çalık AN Özcan KS Yüksel G Güngör B Aruğarslan E Varlibas F Ekmekci A Osmonov D Tatlısu MA Karaca M Bolca O Erdinler I Altered diastolic function and aortic stiffness in Alzheimer’s disease |
| description |
Ali Nazmi Çalik,3 Kazim Serhan Özcan,4 Gülbün Yüksel,2 Baris Güngör,1 Emre Arugarslan,1 Figen Varlibas,2 Ahmet Ekmekci,1 Damirbek Osmonov,1 Mustafa Adem Tatlisu,1 Mehmet Karaca,1 Osman Bolca,1 Izzet Erdinler1 1Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey; 2Department of Neurology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey; 3Department of Cardiology, Yozgat State Hospital, Yozgat, Turkey; 4Department of Cardiology, Derince Training and Research Hospital, Kocaeli, Turkey Background: Alzheimer’s disease (AD) is closely linked to cardiovascular risk factors.Methods: Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and distensibility, on 29 patients with AD and 24 age-matched individuals with normal cognitive function.Results: The peak mitral flow velocity of the early rapid filling wave (E) was lower, and the peak velocity of the late filling wave caused by atrial contraction (A), deceleration time of peak E velocity, and isovolumetric relaxation time were higher in the AD group. The early myocardial peak (Ea) velocity was significantly lower in AD patients, whereas the late diastolic (Aa) velocity and E/Ea ratio were similar between the two groups. In Alzheimer patients, stiffness index and pressure-strain elastic modulus were higher, and distensibility was significantly lower in the AD group compared to the control. Interatrial electromechanical delay was significantly longer in the AD group.Conclusion: Our findings suggest that patients with AD are more likely to have diastolic dysfunction, higher atrial conduction times, and increased arterial stiffness compared to the controls of same sex and similar age. Keywords: diastolic dysfunction, atrial conduction timeA Letter to the Editor has been received and published for this article. |
| format |
article |
| author |
Çalık AN Özcan KS Yüksel G Güngör B Aruğarslan E Varlibas F Ekmekci A Osmonov D Tatlısu MA Karaca M Bolca O Erdinler I |
| author_facet |
Çalık AN Özcan KS Yüksel G Güngör B Aruğarslan E Varlibas F Ekmekci A Osmonov D Tatlısu MA Karaca M Bolca O Erdinler I |
| author_sort |
Çalık AN |
| title |
Altered diastolic function and aortic stiffness in Alzheimer’s disease |
| title_short |
Altered diastolic function and aortic stiffness in Alzheimer’s disease |
| title_full |
Altered diastolic function and aortic stiffness in Alzheimer’s disease |
| title_fullStr |
Altered diastolic function and aortic stiffness in Alzheimer’s disease |
| title_full_unstemmed |
Altered diastolic function and aortic stiffness in Alzheimer’s disease |
| title_sort |
altered diastolic function and aortic stiffness in alzheimer’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/2b08e690bfa640a9b5b94edc9e4699db |
| work_keys_str_mv |
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