Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.

<h4>Background</h4>Rosemary (Rosmarinus officinalis L.) extracts (REs) exhibit hepatoprotective, anti-obesity and anti-inflammatory properties and are widely used in the food industry. REs are rich in carnosic acid (CA) and carnosol which may be responsible for some of the biological act...

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Autores principales:	María Romo Vaquero, María-Josefa Yáñez-Gascón, Rocío García Villalba, Mar Larrosa, Emilie Fromentin, Alvin Ibarra, Marc Roller, Francisco Tomás-Barberán, Juan Carlos Espín de Gea, María-Teresa García-Conesa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b0e95e137d748309f2c5fdaa444ee49
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spelling	oai:doaj.org-article:2b0e95e137d748309f2c5fdaa444ee492021-11-18T07:14:36ZInhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.1932-620310.1371/journal.pone.0039773https://doaj.org/article/2b0e95e137d748309f2c5fdaa444ee492012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22745826/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Rosemary (Rosmarinus officinalis L.) extracts (REs) exhibit hepatoprotective, anti-obesity and anti-inflammatory properties and are widely used in the food industry. REs are rich in carnosic acid (CA) and carnosol which may be responsible for some of the biological activities of REs. The aim of this study was to investigate whether inhibition of lipase activity in the gut may be a mechanism by which a RE enriched in CA (40%) modulates body weight and lipids levels in a rat model of metabolic disorders and obesity.<h4>Methods and principal findings</h4>RE was administered for 64 days to lean (fa/+) and obese (fa/fa) female Zucker rats and body weight, food intake, feces weight and blood biochemical parameters were monitored throughout the study. Lipase activity (hydrolysis of p-nitrophenylbutyrate) was measured in the gastrointestinal tract at the end of the study and the contents of CA, carnosol and methyl carnosate were also determined. Sub-chronic administration of RE moderately reduced body weight gain in both lean and obese animals but did not affect food intake. Serum triglycerides, cholesterol and insulin levels were also markedly decreased in the lean animals supplemented with RE. Importantly, lipase activity was significantly inhibited in the stomach of the RE-supplemented animals where the highest content of intact CA and carnosol was detected.<h4>Conclusions</h4>Our results confirm that long-term administration of RE enriched in CA moderates weight gain and improves the plasma lipids profile, primarily in the lean animals. Our data also suggest that these effects may be caused, at least in part, by a significant inhibition of gastric lipase and subsequent reduction in fat absorption.María Romo VaqueroMaría-Josefa Yáñez-GascónRocío García VillalbaMar LarrosaEmilie FromentinAlvin IbarraMarc RollerFrancisco Tomás-BarberánJuan Carlos Espín de GeaMaría-Teresa García-ConesaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39773 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q María Romo Vaquero María-Josefa Yáñez-Gascón Rocío García Villalba Mar Larrosa Emilie Fromentin Alvin Ibarra Marc Roller Francisco Tomás-Barberán Juan Carlos Espín de Gea María-Teresa García-Conesa Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.
description	<h4>Background</h4>Rosemary (Rosmarinus officinalis L.) extracts (REs) exhibit hepatoprotective, anti-obesity and anti-inflammatory properties and are widely used in the food industry. REs are rich in carnosic acid (CA) and carnosol which may be responsible for some of the biological activities of REs. The aim of this study was to investigate whether inhibition of lipase activity in the gut may be a mechanism by which a RE enriched in CA (40%) modulates body weight and lipids levels in a rat model of metabolic disorders and obesity.<h4>Methods and principal findings</h4>RE was administered for 64 days to lean (fa/+) and obese (fa/fa) female Zucker rats and body weight, food intake, feces weight and blood biochemical parameters were monitored throughout the study. Lipase activity (hydrolysis of p-nitrophenylbutyrate) was measured in the gastrointestinal tract at the end of the study and the contents of CA, carnosol and methyl carnosate were also determined. Sub-chronic administration of RE moderately reduced body weight gain in both lean and obese animals but did not affect food intake. Serum triglycerides, cholesterol and insulin levels were also markedly decreased in the lean animals supplemented with RE. Importantly, lipase activity was significantly inhibited in the stomach of the RE-supplemented animals where the highest content of intact CA and carnosol was detected.<h4>Conclusions</h4>Our results confirm that long-term administration of RE enriched in CA moderates weight gain and improves the plasma lipids profile, primarily in the lean animals. Our data also suggest that these effects may be caused, at least in part, by a significant inhibition of gastric lipase and subsequent reduction in fat absorption.
format	article
author	María Romo Vaquero María-Josefa Yáñez-Gascón Rocío García Villalba Mar Larrosa Emilie Fromentin Alvin Ibarra Marc Roller Francisco Tomás-Barberán Juan Carlos Espín de Gea María-Teresa García-Conesa
author_facet	María Romo Vaquero María-Josefa Yáñez-Gascón Rocío García Villalba Mar Larrosa Emilie Fromentin Alvin Ibarra Marc Roller Francisco Tomás-Barberán Juan Carlos Espín de Gea María-Teresa García-Conesa
author_sort	María Romo Vaquero
title	Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.
title_short	Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.
title_full	Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.
title_fullStr	Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.
title_full_unstemmed	Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.
title_sort	inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in zucker rats fed a rosemary extract rich in carnosic acid.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2b0e95e137d748309f2c5fdaa444ee49
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Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.

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