Frailty transitions and cognitive function among South Korean older adults

Abstract Frailty is considered a multidimensional geriatric syndrome, manifested by the accumulation of age-associated deficits. The consequences of frailty transitions are still understudied. This study evaluated the influence of frailty transitions on cognitive function in the older adult populati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatima Nari, Bich Na Jang, Hin Moi Youn, Wonjeong Jeong, Sung-In Jang, Eun-Cheol Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b135da7f0e64efeb857166e73519907
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2b135da7f0e64efeb857166e73519907
record_format	dspace
spelling	oai:doaj.org-article:2b135da7f0e64efeb857166e735199072021-12-02T14:58:45ZFrailty transitions and cognitive function among South Korean older adults10.1038/s41598-021-90125-62045-2322https://doaj.org/article/2b135da7f0e64efeb857166e735199072021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90125-6https://doaj.org/toc/2045-2322Abstract Frailty is considered a multidimensional geriatric syndrome, manifested by the accumulation of age-associated deficits. The consequences of frailty transitions are still understudied. This study evaluated the influence of frailty transitions on cognitive function in the older adult population. We used data derived from the Korean Longitudinal Study of Aging (KLoSA) (2008–2018) on older adults aged ≥ 65 years. Frailty was assessed using a validated Korean frailty measure known as the frailty instrument (FI), and cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE). Transitions in frailty and their relationship with cognitive function were investigated using lagged generalized estimating equations (GEE), t-tests, and ANOVA. Respondents who experienced frailty transitions (those with ameliorating frailty), those who developed frailty, and whose frailty remained constant, were more likely to have a lower cognitive function than those who were consistently non-frail. Older age, activities of daily living (ADL) disability, and instrumental ADL disability were more negatively associated with declining cognitive function, especially in the “frail → frail” group. Changes in all individual components of the frailty instrument were significantly associated with impaired cognitive function. The results suggest an association between frailty transitions and cognitive impairment. Over a 2-year span, the remaining frail individuals had the highest rate of cognitive decline in men, while the change from non-frail to frail state in women was significantly associated with the lowest cognitive function values. We recommend early interventions and prevention strategies in older adults to help ameliorate or slow down both frailty and cognitive function decline.Fatima NariBich Na JangHin Moi YounWonjeong JeongSung-In JangEun-Cheol ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fatima Nari Bich Na Jang Hin Moi Youn Wonjeong Jeong Sung-In Jang Eun-Cheol Park Frailty transitions and cognitive function among South Korean older adults
description	Abstract Frailty is considered a multidimensional geriatric syndrome, manifested by the accumulation of age-associated deficits. The consequences of frailty transitions are still understudied. This study evaluated the influence of frailty transitions on cognitive function in the older adult population. We used data derived from the Korean Longitudinal Study of Aging (KLoSA) (2008–2018) on older adults aged ≥ 65 years. Frailty was assessed using a validated Korean frailty measure known as the frailty instrument (FI), and cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE). Transitions in frailty and their relationship with cognitive function were investigated using lagged generalized estimating equations (GEE), t-tests, and ANOVA. Respondents who experienced frailty transitions (those with ameliorating frailty), those who developed frailty, and whose frailty remained constant, were more likely to have a lower cognitive function than those who were consistently non-frail. Older age, activities of daily living (ADL) disability, and instrumental ADL disability were more negatively associated with declining cognitive function, especially in the “frail → frail” group. Changes in all individual components of the frailty instrument were significantly associated with impaired cognitive function. The results suggest an association between frailty transitions and cognitive impairment. Over a 2-year span, the remaining frail individuals had the highest rate of cognitive decline in men, while the change from non-frail to frail state in women was significantly associated with the lowest cognitive function values. We recommend early interventions and prevention strategies in older adults to help ameliorate or slow down both frailty and cognitive function decline.
format	article
author	Fatima Nari Bich Na Jang Hin Moi Youn Wonjeong Jeong Sung-In Jang Eun-Cheol Park
author_facet	Fatima Nari Bich Na Jang Hin Moi Youn Wonjeong Jeong Sung-In Jang Eun-Cheol Park
author_sort	Fatima Nari
title	Frailty transitions and cognitive function among South Korean older adults
title_short	Frailty transitions and cognitive function among South Korean older adults
title_full	Frailty transitions and cognitive function among South Korean older adults
title_fullStr	Frailty transitions and cognitive function among South Korean older adults
title_full_unstemmed	Frailty transitions and cognitive function among South Korean older adults
title_sort	frailty transitions and cognitive function among south korean older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2b135da7f0e64efeb857166e73519907
work_keys_str_mv	AT fatimanari frailtytransitionsandcognitivefunctionamongsouthkoreanolderadults AT bichnajang frailtytransitionsandcognitivefunctionamongsouthkoreanolderadults AT hinmoiyoun frailtytransitionsandcognitivefunctionamongsouthkoreanolderadults AT wonjeongjeong frailtytransitionsandcognitivefunctionamongsouthkoreanolderadults AT sunginjang frailtytransitionsandcognitivefunctionamongsouthkoreanolderadults AT euncheolpark frailtytransitionsandcognitivefunctionamongsouthkoreanolderadults
_version_	1718389254209404928

Frailty transitions and cognitive function among South Korean older adults

Ejemplares similares