Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases

Introduction. Morbus Hansen is the infectious disease which causes by bacilli intracellular Mycobacterium leprae which mainly affects the skin and peripheral nerves. The leprosy reaction is an episode an immunologically mediated episode of acute or subacute inflammation which affecting skin; nerve;...

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Autor principal:	Khairuddin Djawad
Formato:	article
Lenguaje:	RU
Publicado:	State Scientific Center of Dermatovenereology and Cosmetology 2021
Materias:	morbus hansen erythema nodosum leprosum pentoxifylline steroid dependence leprosy reaction Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/2b188fe46b2c4e90b38bc1b6106217f0
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spelling	oai:doaj.org-article:2b188fe46b2c4e90b38bc1b6106217f02021-12-01T22:16:29ZPentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases0042-46092313-629410.25208/vdv1196https://doaj.org/article/2b188fe46b2c4e90b38bc1b6106217f02021-03-01T00:00:00Zhttps://vestnikdv.ru/jour/article/viewFile/1196/1188https://doaj.org/toc/0042-4609https://doaj.org/toc/2313-6294Introduction. Morbus Hansen is the infectious disease which causes by bacilli intracellular Mycobacterium leprae which mainly affects the skin and peripheral nerves. The leprosy reaction is an episode an immunologically mediated episode of acute or subacute inflammation which affecting skin; nerve; mucous membrane. Type 2 reactions can be last for months and risk of developing dependence on steroids. Pentoxifylline (PTX) works to hampers the production TNF in vitro and in vivo; are an alternative for ENL treatment. Case Report. One case was reported in a male aged 28 years with complaints of recurring red bumps accompanied by fever and pain. Discussion. On physical examination obtained erythema nodosum; with impaired sensibility in the left leg. The patient experienced improvement after being given therapy of neurodex/24 hours/oral; rifampicin 600 mg; ofloxacin 400 mg; minocycline 100 mg which given 3x for a week; and combination therapy to treat the Leprosy reaction given the combination of methylprednisolone 16mg (3-2-0) and Pentoxifylline 400 mg/8 hours/oral. Conclusion. In the 21 day of treatment; the redness lump improved in the middle finger and left arm was gone. No new reddish bumps appeared and less tingling sensation.Khairuddin DjawadState Scientific Center of Dermatovenereology and Cosmetologyarticlemorbus hansenerythema nodosum leprosumpentoxifyllinesteroid dependenceleprosy reactionDermatologyRL1-803RUVestnik Dermatologii i Venerologii, Vol 97, Iss 1, Pp 46-53 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	morbus hansen erythema nodosum leprosum pentoxifylline steroid dependence leprosy reaction Dermatology RL1-803
spellingShingle	morbus hansen erythema nodosum leprosum pentoxifylline steroid dependence leprosy reaction Dermatology RL1-803 Khairuddin Djawad Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases
description	Introduction. Morbus Hansen is the infectious disease which causes by bacilli intracellular Mycobacterium leprae which mainly affects the skin and peripheral nerves. The leprosy reaction is an episode an immunologically mediated episode of acute or subacute inflammation which affecting skin; nerve; mucous membrane. Type 2 reactions can be last for months and risk of developing dependence on steroids. Pentoxifylline (PTX) works to hampers the production TNF in vitro and in vivo; are an alternative for ENL treatment. Case Report. One case was reported in a male aged 28 years with complaints of recurring red bumps accompanied by fever and pain. Discussion. On physical examination obtained erythema nodosum; with impaired sensibility in the left leg. The patient experienced improvement after being given therapy of neurodex/24 hours/oral; rifampicin 600 mg; ofloxacin 400 mg; minocycline 100 mg which given 3x for a week; and combination therapy to treat the Leprosy reaction given the combination of methylprednisolone 16mg (3-2-0) and Pentoxifylline 400 mg/8 hours/oral. Conclusion. In the 21 day of treatment; the redness lump improved in the middle finger and left arm was gone. No new reddish bumps appeared and less tingling sensation.
format	article
author	Khairuddin Djawad
author_facet	Khairuddin Djawad
author_sort	Khairuddin Djawad
title	Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases
title_short	Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases
title_full	Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases
title_fullStr	Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases
title_full_unstemmed	Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases
title_sort	pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases
publisher	State Scientific Center of Dermatovenereology and Cosmetology
publishDate	2021
url	https://doaj.org/article/2b188fe46b2c4e90b38bc1b6106217f0
work_keys_str_mv	AT khairuddindjawad pentoxifyllinetherapyforpatientswithtype2leprosyreactionserythemanodosumleprosuminsteroiddependentcases
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Pentoxifylline therapy for patients with type 2 leprosy reactions: erythema nodosum leprosum in steroid-dependent cases

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