Signalome-wide assessment of host cell response to hepatitis C virus

Development of antiviral strategies depends on an understanding of virus–host interactions. Here, using HCV, Haqshenaset al. show that antibody microarray combined with a targeted siRNA screen can be a powerful tool to identify cellular signalling pathways that are important for virus replication.

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Detalles Bibliográficos
Autores principales: Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2b1ab52c86cf420faa917a8f8b0408df
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Descripción
Sumario:Development of antiviral strategies depends on an understanding of virus–host interactions. Here, using HCV, Haqshenaset al. show that antibody microarray combined with a targeted siRNA screen can be a powerful tool to identify cellular signalling pathways that are important for virus replication.