A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography

Studying changes in cortical oscillations can help elucidate the mechanistic link between receptor physiology and the clinical effects of anaesthetic drugs. Propofol, a GABA-ergic drug produces divergent effects on visual cortical activity: increasing induced gamma-band responses (GBR) while decreas...

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Autores principales:	Neeraj Saxena, Suresh D. Muthukumaraswamy, Lewys Richmond, Adele Babic, Krish D. Singh, Judith E. Hall, Richard G. Wise, Alexander D. Shaw
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Magnetoencephalography Oscillations Neurophysiology Propofol Dexmedetomidine Conscious sedation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/2b1fe888dbea4781a67e362ad34197ba
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spelling	oai:doaj.org-article:2b1fe888dbea4781a67e362ad34197ba2021-11-18T04:44:55ZA comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography1095-957210.1016/j.neuroimage.2021.118659https://doaj.org/article/2b1fe888dbea4781a67e362ad34197ba2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009320https://doaj.org/toc/1095-9572Studying changes in cortical oscillations can help elucidate the mechanistic link between receptor physiology and the clinical effects of anaesthetic drugs. Propofol, a GABA-ergic drug produces divergent effects on visual cortical activity: increasing induced gamma-band responses (GBR) while decreasing evoked responses. Dexmedetomidine, an α2- adrenergic agonist, differs from GABA-ergic sedatives both mechanistically and clinically as it allows easy arousability from deep sedation with less cognitive side-effects. Here we use magnetoencephalography (MEG) to characterize and compare the effects of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation, on visual and motor cortical oscillations. Sixteen male participants received target-controlled infusions of propofol and dexmedetomidine, producing mild-sedation, in a placebo-controlled, cross-over study. MEG data was collected during a combined visuomotor task. The key findings were that propofol significantly enhanced visual stimulus induced GBR (44% increase in amplitude) while dexmedetomidine decreased it (40%). Propofol also decreased the amplitudes of the Mv100 (visual M100) (27%) and Mv150 (52%) visual evoked fields (VEF), whilst dexmedetomidine had no effect on these. During the motor task, neither drug had any significant effect on movement related gamma synchrony (MRGS), movement related beta de-synchronisation (MRBD) or Mm100 (movement-related M100) movement-related evoked fields (MEF), although dexmedetomidine slowed the Mm300. Dexmedetomidine increased (92%) post-movement beta synchronisation/rebound (PMBR) power while propofol reduced it (70%, statistically non- significant). Overall, dexmedetomidine and propofol, at equi-sedative doses, produce contrasting effects on visual induced GBR, VEF, PMBR and MEF. These findings provide a mechanistic link between the known receptor physiology of these sedative drugs with their known clinical effects and may be used to explore mechanisms of other anaesthetic drugs on human consciousness.Neeraj SaxenaSuresh D. MuthukumaraswamyLewys RichmondAdele BabicKrish D. SinghJudith E. HallRichard G. WiseAlexander D. ShawElsevierarticleMagnetoencephalographyOscillationsNeurophysiologyPropofolDexmedetomidineConscious sedationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118659- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Magnetoencephalography Oscillations Neurophysiology Propofol Dexmedetomidine Conscious sedation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Magnetoencephalography Oscillations Neurophysiology Propofol Dexmedetomidine Conscious sedation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neeraj Saxena Suresh D. Muthukumaraswamy Lewys Richmond Adele Babic Krish D. Singh Judith E. Hall Richard G. Wise Alexander D. Shaw A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
description	Studying changes in cortical oscillations can help elucidate the mechanistic link between receptor physiology and the clinical effects of anaesthetic drugs. Propofol, a GABA-ergic drug produces divergent effects on visual cortical activity: increasing induced gamma-band responses (GBR) while decreasing evoked responses. Dexmedetomidine, an α2- adrenergic agonist, differs from GABA-ergic sedatives both mechanistically and clinically as it allows easy arousability from deep sedation with less cognitive side-effects. Here we use magnetoencephalography (MEG) to characterize and compare the effects of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation, on visual and motor cortical oscillations. Sixteen male participants received target-controlled infusions of propofol and dexmedetomidine, producing mild-sedation, in a placebo-controlled, cross-over study. MEG data was collected during a combined visuomotor task. The key findings were that propofol significantly enhanced visual stimulus induced GBR (44% increase in amplitude) while dexmedetomidine decreased it (40%). Propofol also decreased the amplitudes of the Mv100 (visual M100) (27%) and Mv150 (52%) visual evoked fields (VEF), whilst dexmedetomidine had no effect on these. During the motor task, neither drug had any significant effect on movement related gamma synchrony (MRGS), movement related beta de-synchronisation (MRBD) or Mm100 (movement-related M100) movement-related evoked fields (MEF), although dexmedetomidine slowed the Mm300. Dexmedetomidine increased (92%) post-movement beta synchronisation/rebound (PMBR) power while propofol reduced it (70%, statistically non- significant). Overall, dexmedetomidine and propofol, at equi-sedative doses, produce contrasting effects on visual induced GBR, VEF, PMBR and MEF. These findings provide a mechanistic link between the known receptor physiology of these sedative drugs with their known clinical effects and may be used to explore mechanisms of other anaesthetic drugs on human consciousness.
format	article
author	Neeraj Saxena Suresh D. Muthukumaraswamy Lewys Richmond Adele Babic Krish D. Singh Judith E. Hall Richard G. Wise Alexander D. Shaw
author_facet	Neeraj Saxena Suresh D. Muthukumaraswamy Lewys Richmond Adele Babic Krish D. Singh Judith E. Hall Richard G. Wise Alexander D. Shaw
author_sort	Neeraj Saxena
title	A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
title_short	A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
title_full	A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
title_fullStr	A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
title_full_unstemmed	A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
title_sort	comparison of gaba-ergic (propofol) and non-gaba-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2b1fe888dbea4781a67e362ad34197ba
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A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography

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