The survival rate of Iranian breast cancer patients with focus on prognostic factors

Introduction: Breast cancer is the most prevalent cancer in women. Several studies showed that TNM stage, grade cancer, lymph node involvement, and the status of hormone receptors are the most important factor of breast cancer prognosis. Objectives: To evaluate the clinical characteristics, prognost...

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Autores principales:	Abdolhasan Talaiezadeh, Saghar Babadi, Pedram Nazari
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2022
Materias:	breast cancer survival prognostic factors iran Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/2b232f67214045db87aa35882abf3086
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spelling	oai:doaj.org-article:2b232f67214045db87aa35882abf30862021-11-16T10:42:13ZThe survival rate of Iranian breast cancer patients with focus on prognostic factors2476-393410.34172/jpe.2022.13https://doaj.org/article/2b232f67214045db87aa35882abf30862022-01-01T00:00:00Zhttps://jprevepi.com/PDF/jpe-7-e13.pdfhttps://doaj.org/toc/2476-3934Introduction: Breast cancer is the most prevalent cancer in women. Several studies showed that TNM stage, grade cancer, lymph node involvement, and the status of hormone receptors are the most important factor of breast cancer prognosis. Objectives: To evaluate the clinical characteristics, prognostic factors, and survival rate in patients with breast cancer who underwent surgery in Ahvaz, Southwest of Iran. Patients and Methods: This historical cohort study was conducted on 561 patients who underwent surgery for breast cancer between May 1997 and June 2016. Clinical characteristics, pathological profile, stage, and treatments of the patients were recorded. The prognostic factor, two and five-year overall survival (OS) rates, disease-free survival (DFS) were evaluated by the Cox proportional hazards model and the Kaplan-Meier test, respectively. Results: The two and five-year OS rates were 92.1% and 81.7%, respectively. The most important prognostic factors in breast cancer survival were age, the size of the tumor, regional lymph node involvement, metastasis, stage, relapse, estrogen receptor (ER), progesterone receptor (PR), and hormone therapy. There was no significant relationship between tumor type, tumor site, metastasis, surgery kind, chemotherapy, radiation therapy, and the status of human epidermal growth factor receptor 2 (HER2) and the five-year survival rate. Conclusion: This study showed that the most important factors affecting the high survival rate of patients with breast cancer are hormonal receptors, non-involvement of the lymph nodes, early-stage cancer, no recurrence, and no metastasis.Abdolhasan TalaiezadehSaghar BabadiPedram NazariSociety of Diabetic Nephropathy Preventionarticlebreast cancersurvivalprognostic factorsiranSpecialties of internal medicineRC581-951Infectious and parasitic diseasesRC109-216ENJournal of Preventive Epidemiology, Vol 7, Iss 1, Pp e13-e13 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer survival prognostic factors iran Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
spellingShingle	breast cancer survival prognostic factors iran Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216 Abdolhasan Talaiezadeh Saghar Babadi Pedram Nazari The survival rate of Iranian breast cancer patients with focus on prognostic factors
description	Introduction: Breast cancer is the most prevalent cancer in women. Several studies showed that TNM stage, grade cancer, lymph node involvement, and the status of hormone receptors are the most important factor of breast cancer prognosis. Objectives: To evaluate the clinical characteristics, prognostic factors, and survival rate in patients with breast cancer who underwent surgery in Ahvaz, Southwest of Iran. Patients and Methods: This historical cohort study was conducted on 561 patients who underwent surgery for breast cancer between May 1997 and June 2016. Clinical characteristics, pathological profile, stage, and treatments of the patients were recorded. The prognostic factor, two and five-year overall survival (OS) rates, disease-free survival (DFS) were evaluated by the Cox proportional hazards model and the Kaplan-Meier test, respectively. Results: The two and five-year OS rates were 92.1% and 81.7%, respectively. The most important prognostic factors in breast cancer survival were age, the size of the tumor, regional lymph node involvement, metastasis, stage, relapse, estrogen receptor (ER), progesterone receptor (PR), and hormone therapy. There was no significant relationship between tumor type, tumor site, metastasis, surgery kind, chemotherapy, radiation therapy, and the status of human epidermal growth factor receptor 2 (HER2) and the five-year survival rate. Conclusion: This study showed that the most important factors affecting the high survival rate of patients with breast cancer are hormonal receptors, non-involvement of the lymph nodes, early-stage cancer, no recurrence, and no metastasis.
format	article
author	Abdolhasan Talaiezadeh Saghar Babadi Pedram Nazari
author_facet	Abdolhasan Talaiezadeh Saghar Babadi Pedram Nazari
author_sort	Abdolhasan Talaiezadeh
title	The survival rate of Iranian breast cancer patients with focus on prognostic factors
title_short	The survival rate of Iranian breast cancer patients with focus on prognostic factors
title_full	The survival rate of Iranian breast cancer patients with focus on prognostic factors
title_fullStr	The survival rate of Iranian breast cancer patients with focus on prognostic factors
title_full_unstemmed	The survival rate of Iranian breast cancer patients with focus on prognostic factors
title_sort	survival rate of iranian breast cancer patients with focus on prognostic factors
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2022
url	https://doaj.org/article/2b232f67214045db87aa35882abf3086
work_keys_str_mv	AT abdolhasantalaiezadeh thesurvivalrateofiranianbreastcancerpatientswithfocusonprognosticfactors AT sagharbabadi thesurvivalrateofiranianbreastcancerpatientswithfocusonprognosticfactors AT pedramnazari thesurvivalrateofiranianbreastcancerpatientswithfocusonprognosticfactors AT abdolhasantalaiezadeh survivalrateofiranianbreastcancerpatientswithfocusonprognosticfactors AT sagharbabadi survivalrateofiranianbreastcancerpatientswithfocusonprognosticfactors AT pedramnazari survivalrateofiranianbreastcancerpatientswithfocusonprognosticfactors
_version_	1718426532436770816

The survival rate of Iranian breast cancer patients with focus on prognostic factors

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