Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.

The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm...

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Autores principales:	Piotr Orlowski, Emilia Tomaszewska, Marianna Gniadek, Piotr Baska, Julita Nowakowska, Justyna Sokolowska, Zuzanna Nowak, Mikolaj Donten, Grzegorz Celichowski, Jaroslaw Grobelny, Malgorzata Krzyzowska
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b23309e0a72448f9202c6b4f262b89f
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spelling	oai:doaj.org-article:2b23309e0a72448f9202c6b4f262b89f2021-11-25T06:05:13ZTannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.1932-620310.1371/journal.pone.0104113https://doaj.org/article/2b23309e0a72448f9202c6b4f262b89f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25117537/?tool=EBIhttps://doaj.org/toc/1932-6203The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm are capable of reducing HSV-2 infectivity both in vitro and in vivo. The antiviral activity of tannic acid modified silver nanoparticles was size-related, required direct interaction and blocked virus attachment, penetration and further spread. All tested tannic acid modified silver nanoparticles reduced both infection and inflammatory reaction in the mouse model of HSV-2 infection when used at infection or for a post-infection treatment. Smaller-sized nanoparticles induced production of cytokines and chemokines important for anti-viral response. The corresponding control buffers with tannic acid showed inferior antiviral effects in vitro and were ineffective in blocking in vivo infection. Our results show that tannic acid modified silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections.Piotr OrlowskiEmilia TomaszewskaMarianna GniadekPiotr BaskaJulita NowakowskaJustyna SokolowskaZuzanna NowakMikolaj DontenGrzegorz CelichowskiJaroslaw GrobelnyMalgorzata KrzyzowskaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104113 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Piotr Orlowski Emilia Tomaszewska Marianna Gniadek Piotr Baska Julita Nowakowska Justyna Sokolowska Zuzanna Nowak Mikolaj Donten Grzegorz Celichowski Jaroslaw Grobelny Malgorzata Krzyzowska Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
description	The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm are capable of reducing HSV-2 infectivity both in vitro and in vivo. The antiviral activity of tannic acid modified silver nanoparticles was size-related, required direct interaction and blocked virus attachment, penetration and further spread. All tested tannic acid modified silver nanoparticles reduced both infection and inflammatory reaction in the mouse model of HSV-2 infection when used at infection or for a post-infection treatment. Smaller-sized nanoparticles induced production of cytokines and chemokines important for anti-viral response. The corresponding control buffers with tannic acid showed inferior antiviral effects in vitro and were ineffective in blocking in vivo infection. Our results show that tannic acid modified silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections.
format	article
author	Piotr Orlowski Emilia Tomaszewska Marianna Gniadek Piotr Baska Julita Nowakowska Justyna Sokolowska Zuzanna Nowak Mikolaj Donten Grzegorz Celichowski Jaroslaw Grobelny Malgorzata Krzyzowska
author_facet	Piotr Orlowski Emilia Tomaszewska Marianna Gniadek Piotr Baska Julita Nowakowska Justyna Sokolowska Zuzanna Nowak Mikolaj Donten Grzegorz Celichowski Jaroslaw Grobelny Malgorzata Krzyzowska
author_sort	Piotr Orlowski
title	Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
title_short	Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
title_full	Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
title_fullStr	Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
title_full_unstemmed	Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
title_sort	tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/2b23309e0a72448f9202c6b4f262b89f
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Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.

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