Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice.

Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice.

Vitamin D3 (VD3) induces intestinal CYP3A that metabolizes orally administered anti-leukemic chemotherapeutic substrates dexamethasone (DEX) and dasatinib potentially causing a vitamin-drug interaction. To determine the impact of VD3 status on systemic exposure and efficacy of these chemotherapeutic...

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Bibliographic Details
Main Authors: Kavya Annu, Kazuto Yasuda, William V Caufield, Burgess B Freeman, Erin G Schuetz
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/2b256692a0f8435c85bc1753e5748a00
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