Clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm

Abstract Purpose Solid pseudopapillary neoplasm (SPN) is an uncommon pathology with a low-grade malignancy. Surgery is the milestone treatment. Nevertheless, despite appropriate management, some patients present recurrence. Risk factors associated with recurrence are unclear. The objective was to id...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Oscar Paredes, Kori Paredes, Yoshikuni Kawaguchi, Carlos Luque-Vasquez, Iván Chavez, Juan Celis, Eduardo Payet, Eloy Ruiz, Francisco Berrospi
Formato: article
Lenguaje:EN
Publicado: Springer 2021
Materias:
Acceso en línea:https://doaj.org/article/2b277d061e644e46bfd34111ae72e0d1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2b277d061e644e46bfd34111ae72e0d1
record_format dspace
spelling oai:doaj.org-article:2b277d061e644e46bfd34111ae72e0d12021-11-28T12:42:04ZClinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm10.1007/s12672-021-00451-42730-6011https://doaj.org/article/2b277d061e644e46bfd34111ae72e0d12021-11-01T00:00:00Zhttps://doi.org/10.1007/s12672-021-00451-4https://doaj.org/toc/2730-6011Abstract Purpose Solid pseudopapillary neoplasm (SPN) is an uncommon pathology with a low-grade malignancy. Surgery is the milestone treatment. Nevertheless, despite appropriate management, some patients present recurrence. Risk factors associated with recurrence are unclear. The objective was to identify the clinicopathological factors associated with recurrence in patients with SPN treated with pancreatic resection. Methods Medical records of patients treated with pancreatic resection during 2006–2020 were evaluated. Patients with histological diagnosis of SPN were included. Survival analysis was performed to identify the clinicopathological factors related to recurrence. Results Seventy-four patients were diagnosed with SPN; 70 (94.6%) patients were female, and the median age was 20 years old. The median tumor diameter was 7.9 cm. Multivisceral resection was performed in 9 (12.2%) patients. Four (5.4%) patients presented lymph node metastasis.R0 resection was achieved in all cases. Six (8%) patients presented recurrence and the liver was the most frequent recurrence site (n = 5).After a median follow-up of 40.2 months, 9 (12%) patients died. Five (6.8%) patients died of disease progression. The 1–3- and 5-year overall survival (OS) was 97.1%, 90.2% and 79.9%, respectively. The 1–3-and-5-year recurrence-free survival (RFS) was 98.4%, 89.9% and 87%, respectively. In the univariate Cox-regression analysis, age ≥ 28 years(HR = 8.61, 95% CI 1.1–73.8),tumor diameter ≥ 10 cm(HR = 9.3, 95% CI 1.12–79.6),invasion of adjacent organs (HR = 7.45, 95% CI 1.5–36.9), lymph node metastasis (pN +) (HR = 16.8, 95% CI 2.96–94.9) and, AJCC Stage III (HR = 10.1, 95% CI 1.2–90.9) were identified as predictors for recurrence. Conclusions SPN is more frequently diagnosed in young women with a good overall prognosis after an R0 surgical resection even with disease recurrence. Age ≥ 28 years, larger tumors ≥ 10 cm, invasion of adjacent organs, lymph node metastasis(pN +) and, AJCC Stage III were predictors factors of recurrence in resected SPN.Oscar ParedesKori ParedesYoshikuni KawaguchiCarlos Luque-VasquezIván ChavezJuan CelisEduardo PayetEloy RuizFrancisco BerrospiSpringerarticlePancreasPseudopapillary neoplasm (SPN)RecurrenceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENDiscover Oncology, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Pancreas
Pseudopapillary neoplasm (SPN)
Recurrence
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Pancreas
Pseudopapillary neoplasm (SPN)
Recurrence
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Oscar Paredes
Kori Paredes
Yoshikuni Kawaguchi
Carlos Luque-Vasquez
Iván Chavez
Juan Celis
Eduardo Payet
Eloy Ruiz
Francisco Berrospi
Clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm
description Abstract Purpose Solid pseudopapillary neoplasm (SPN) is an uncommon pathology with a low-grade malignancy. Surgery is the milestone treatment. Nevertheless, despite appropriate management, some patients present recurrence. Risk factors associated with recurrence are unclear. The objective was to identify the clinicopathological factors associated with recurrence in patients with SPN treated with pancreatic resection. Methods Medical records of patients treated with pancreatic resection during 2006–2020 were evaluated. Patients with histological diagnosis of SPN were included. Survival analysis was performed to identify the clinicopathological factors related to recurrence. Results Seventy-four patients were diagnosed with SPN; 70 (94.6%) patients were female, and the median age was 20 years old. The median tumor diameter was 7.9 cm. Multivisceral resection was performed in 9 (12.2%) patients. Four (5.4%) patients presented lymph node metastasis.R0 resection was achieved in all cases. Six (8%) patients presented recurrence and the liver was the most frequent recurrence site (n = 5).After a median follow-up of 40.2 months, 9 (12%) patients died. Five (6.8%) patients died of disease progression. The 1–3- and 5-year overall survival (OS) was 97.1%, 90.2% and 79.9%, respectively. The 1–3-and-5-year recurrence-free survival (RFS) was 98.4%, 89.9% and 87%, respectively. In the univariate Cox-regression analysis, age ≥ 28 years(HR = 8.61, 95% CI 1.1–73.8),tumor diameter ≥ 10 cm(HR = 9.3, 95% CI 1.12–79.6),invasion of adjacent organs (HR = 7.45, 95% CI 1.5–36.9), lymph node metastasis (pN +) (HR = 16.8, 95% CI 2.96–94.9) and, AJCC Stage III (HR = 10.1, 95% CI 1.2–90.9) were identified as predictors for recurrence. Conclusions SPN is more frequently diagnosed in young women with a good overall prognosis after an R0 surgical resection even with disease recurrence. Age ≥ 28 years, larger tumors ≥ 10 cm, invasion of adjacent organs, lymph node metastasis(pN +) and, AJCC Stage III were predictors factors of recurrence in resected SPN.
format article
author Oscar Paredes
Kori Paredes
Yoshikuni Kawaguchi
Carlos Luque-Vasquez
Iván Chavez
Juan Celis
Eduardo Payet
Eloy Ruiz
Francisco Berrospi
author_facet Oscar Paredes
Kori Paredes
Yoshikuni Kawaguchi
Carlos Luque-Vasquez
Iván Chavez
Juan Celis
Eduardo Payet
Eloy Ruiz
Francisco Berrospi
author_sort Oscar Paredes
title Clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm
title_short Clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm
title_full Clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm
title_fullStr Clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm
title_full_unstemmed Clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm
title_sort clinicopathological factors associated with recurrence in patients undergoing resection of pancreatic solid pseudopapillary neoplasm
publisher Springer
publishDate 2021
url https://doaj.org/article/2b277d061e644e46bfd34111ae72e0d1
work_keys_str_mv AT oscarparedes clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT koriparedes clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT yoshikunikawaguchi clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT carlosluquevasquez clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT ivanchavez clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT juancelis clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT eduardopayet clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT eloyruiz clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
AT franciscoberrospi clinicopathologicalfactorsassociatedwithrecurrenceinpatientsundergoingresectionofpancreaticsolidpseudopapillaryneoplasm
_version_ 1718407823065350144