Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.

It remains unclear whether white matter (WM) changes found in post-traumatic stress disorder (PTSD) patients are stress-induced or precursors for vulnerability. The current study aimed to identify susceptibility factors relating to the development of PTSD and to examine the ability of these factors...

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Autores principales:	Yawen Sun, Zhen Wang, Weina Ding, Jieqing Wan, Zhiguo Zhuang, Yong Zhang, Yijun Liu, Yan Zhou, Jianrong Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b290d805c02438381871a651aea996f
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spelling	oai:doaj.org-article:2b290d805c02438381871a651aea996f2021-11-18T08:41:57ZAlterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.1932-620310.1371/journal.pone.0083473https://doaj.org/article/2b290d805c02438381871a651aea996f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349515/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203It remains unclear whether white matter (WM) changes found in post-traumatic stress disorder (PTSD) patients are stress-induced or precursors for vulnerability. The current study aimed to identify susceptibility factors relating to the development of PTSD and to examine the ability of these factors to predict the course of longitudinal PTSD. Sixty two victims who had experienced traffic accidents underwent diffusion tensor imaging using a 3.0T MRI system within 2 days after their accidents. Of these, 21 were diagnosed with PTSD at 1 or 6 months using the Clinician-Administered Ptsd Scale (CAPS). Then, 11 trauma-exposed victims with PTSD underwent the second MRI scan. Compared with the victims without PTSD, the victims with PTSD showed decreased fractional anisotropy (FA) in WM of the anterior cingulate cortex, ventromedial prefrontal cortex (vmPFC), temporal lobes and midbrain, and increased mean diffusivity (MD) in the vmPFC within 2 days after the traumatic event. Importantly, decreased FA of the vmPFC in the acute phase predicted greater future CAPS scores. In addition, we found decreased FA in the insula in the follow-up scan in the victims with PTSD, which correlated with the decreased FA of the vmPFC in their baseline scan. These results suggested that the WM might have changed within 2 days after the traumatic event in the individuals who would later develop PTSD. Furthermore, decreased FA of the vmPFC could be a possible vulnerability marker predicting future development of PTSD and may provide an outcome prediction of the acquired signs.Yawen SunZhen WangWeina DingJieqing WanZhiguo ZhuangYong ZhangYijun LiuYan ZhouJianrong XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83473 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yawen Sun Zhen Wang Weina Ding Jieqing Wan Zhiguo Zhuang Yong Zhang Yijun Liu Yan Zhou Jianrong Xu Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.
description	It remains unclear whether white matter (WM) changes found in post-traumatic stress disorder (PTSD) patients are stress-induced or precursors for vulnerability. The current study aimed to identify susceptibility factors relating to the development of PTSD and to examine the ability of these factors to predict the course of longitudinal PTSD. Sixty two victims who had experienced traffic accidents underwent diffusion tensor imaging using a 3.0T MRI system within 2 days after their accidents. Of these, 21 were diagnosed with PTSD at 1 or 6 months using the Clinician-Administered Ptsd Scale (CAPS). Then, 11 trauma-exposed victims with PTSD underwent the second MRI scan. Compared with the victims without PTSD, the victims with PTSD showed decreased fractional anisotropy (FA) in WM of the anterior cingulate cortex, ventromedial prefrontal cortex (vmPFC), temporal lobes and midbrain, and increased mean diffusivity (MD) in the vmPFC within 2 days after the traumatic event. Importantly, decreased FA of the vmPFC in the acute phase predicted greater future CAPS scores. In addition, we found decreased FA in the insula in the follow-up scan in the victims with PTSD, which correlated with the decreased FA of the vmPFC in their baseline scan. These results suggested that the WM might have changed within 2 days after the traumatic event in the individuals who would later develop PTSD. Furthermore, decreased FA of the vmPFC could be a possible vulnerability marker predicting future development of PTSD and may provide an outcome prediction of the acquired signs.
format	article
author	Yawen Sun Zhen Wang Weina Ding Jieqing Wan Zhiguo Zhuang Yong Zhang Yijun Liu Yan Zhou Jianrong Xu
author_facet	Yawen Sun Zhen Wang Weina Ding Jieqing Wan Zhiguo Zhuang Yong Zhang Yijun Liu Yan Zhou Jianrong Xu
author_sort	Yawen Sun
title	Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.
title_short	Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.
title_full	Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.
title_fullStr	Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.
title_full_unstemmed	Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.
title_sort	alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced ptsd.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2b290d805c02438381871a651aea996f
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Alterations in white matter microstructure as vulnerability factors and acquired signs of traffic accident-induced PTSD.

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