A redox mechanism underlying nucleolar stress sensing by nucleophosmin

A redox mechanism underlying nucleolar stress sensing by nucleophosmin

Nucleoplasmic translocation of NPM1 is integral to nucleolar stress sensing. Here, the authors show that nucleolar oxidation is a general cellular stress response, and that oxidation-related glutathionylation of NPM1 triggers its translocation and facilitates p53 activation.

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Autores principales: Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang, Jing Yi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2b29b5fcbce44497824d67dce401b39c
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spelling oai:doaj.org-article:2b29b5fcbce44497824d67dce401b39c2021-12-02T15:34:32ZA redox mechanism underlying nucleolar stress sensing by nucleophosmin10.1038/ncomms135992041-1723https://doaj.org/article/2b29b5fcbce44497824d67dce401b39c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13599https://doaj.org/toc/2041-1723Nucleoplasmic translocation of NPM1 is integral to nucleolar stress sensing. Here, the authors show that nucleolar oxidation is a general cellular stress response, and that oxidation-related glutathionylation of NPM1 triggers its translocation and facilitates p53 activation.Kai YangMing WangYuzheng ZhaoXuxu SunYi YangXie LiAiwu ZhouHuilin ChuHu ZhouJianrong XuMian WuJie YangJing YiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kai Yang
Ming Wang
Yuzheng Zhao
Xuxu Sun
Yi Yang
Xie Li
Aiwu Zhou
Huilin Chu
Hu Zhou
Jianrong Xu
Mian Wu
Jie Yang
Jing Yi
A redox mechanism underlying nucleolar stress sensing by nucleophosmin
description Nucleoplasmic translocation of NPM1 is integral to nucleolar stress sensing. Here, the authors show that nucleolar oxidation is a general cellular stress response, and that oxidation-related glutathionylation of NPM1 triggers its translocation and facilitates p53 activation.
format article
author Kai Yang
Ming Wang
Yuzheng Zhao
Xuxu Sun
Yi Yang
Xie Li
Aiwu Zhou
Huilin Chu
Hu Zhou
Jianrong Xu
Mian Wu
Jie Yang
Jing Yi
author_facet Kai Yang
Ming Wang
Yuzheng Zhao
Xuxu Sun
Yi Yang
Xie Li
Aiwu Zhou
Huilin Chu
Hu Zhou
Jianrong Xu
Mian Wu
Jie Yang
Jing Yi
author_sort Kai Yang
title A redox mechanism underlying nucleolar stress sensing by nucleophosmin
title_short A redox mechanism underlying nucleolar stress sensing by nucleophosmin
title_full A redox mechanism underlying nucleolar stress sensing by nucleophosmin
title_fullStr A redox mechanism underlying nucleolar stress sensing by nucleophosmin
title_full_unstemmed A redox mechanism underlying nucleolar stress sensing by nucleophosmin
title_sort redox mechanism underlying nucleolar stress sensing by nucleophosmin
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/2b29b5fcbce44497824d67dce401b39c
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