Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris

Coronary vasomotion disorders represent a frequent cause of angina and/or dyspnoea in patients with non-obstructed coronary arteries. The highly sophisticated interplay of vasodilatation and vasoconstriction can be assessed in an interventional diagnostic procedure. Established parameters characteri...

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Autores principales:	Sascha Beck, Valeria Martínez Pereyra, Andreas Seitz, Johanna McChord, Astrid Hubert, Raffi Bekeredjian, Udo Sechtem, Peter Ong
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/2b2a8494b8ab4f19aa1c80a2079474dd
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spelling	oai:doaj.org-article:2b2a8494b8ab4f19aa1c80a2079474dd2021-12-04T16:04:40ZInvasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris10.15420/ecr.2021.061758-37641758-3756https://doaj.org/article/2b2a8494b8ab4f19aa1c80a2079474dd2021-07-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2021.06https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Coronary vasomotion disorders represent a frequent cause of angina and/or dyspnoea in patients with non-obstructed coronary arteries. The highly sophisticated interplay of vasodilatation and vasoconstriction can be assessed in an interventional diagnostic procedure. Established parameters characterising adequate vasodilatation are coronary blood flow at rest, and, after drug-induced vasodilation, coronary flow reserve, and microvascular resistance (hyperaemic microvascular resistance, index of microcirculatory resistance). An increased vasoconstrictive potential is diagnosed by provocation testing with acetylcholine or ergonovine. This enables a diagnosis of coronary epicardial and/or microvascular spasm. Ischaemia associated with microvascular spasm can be confirmed by ischaemic ECG changes and the measurement of lactate concentrations in the coronary sinus. Although interventional diagnostic procedures are helpful for determining the mechanism of the angina, which may be the key to successful medical treatment, they are still neither widely accepted nor applied in many medical centres. This article summarises currently well-established invasive methods for the diagnosis of coronary functional disorders causing angina pectoris.Sascha BeckValeria Martínez PereyraAndreas SeitzJohanna McChordAstrid HubertRaffi BekeredjianUdo SechtemPeter OngRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 16, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Sascha Beck Valeria Martínez Pereyra Andreas Seitz Johanna McChord Astrid Hubert Raffi Bekeredjian Udo Sechtem Peter Ong Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris
description	Coronary vasomotion disorders represent a frequent cause of angina and/or dyspnoea in patients with non-obstructed coronary arteries. The highly sophisticated interplay of vasodilatation and vasoconstriction can be assessed in an interventional diagnostic procedure. Established parameters characterising adequate vasodilatation are coronary blood flow at rest, and, after drug-induced vasodilation, coronary flow reserve, and microvascular resistance (hyperaemic microvascular resistance, index of microcirculatory resistance). An increased vasoconstrictive potential is diagnosed by provocation testing with acetylcholine or ergonovine. This enables a diagnosis of coronary epicardial and/or microvascular spasm. Ischaemia associated with microvascular spasm can be confirmed by ischaemic ECG changes and the measurement of lactate concentrations in the coronary sinus. Although interventional diagnostic procedures are helpful for determining the mechanism of the angina, which may be the key to successful medical treatment, they are still neither widely accepted nor applied in many medical centres. This article summarises currently well-established invasive methods for the diagnosis of coronary functional disorders causing angina pectoris.
format	article
author	Sascha Beck Valeria Martínez Pereyra Andreas Seitz Johanna McChord Astrid Hubert Raffi Bekeredjian Udo Sechtem Peter Ong
author_facet	Sascha Beck Valeria Martínez Pereyra Andreas Seitz Johanna McChord Astrid Hubert Raffi Bekeredjian Udo Sechtem Peter Ong
author_sort	Sascha Beck
title	Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris
title_short	Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris
title_full	Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris
title_fullStr	Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris
title_full_unstemmed	Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris
title_sort	invasive diagnosis of coronary functional disorders causing angina pectoris
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/2b2a8494b8ab4f19aa1c80a2079474dd
work_keys_str_mv	AT saschabeck invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris AT valeriamartinezpereyra invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris AT andreasseitz invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris AT johannamcchord invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris AT astridhubert invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris AT raffibekeredjian invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris AT udosechtem invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris AT peterong invasivediagnosisofcoronaryfunctionaldisorderscausinganginapectoris
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Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris

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