Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?

Objective:Free hormones are biologically more active in target tissues. Thus, measurement of vitamin D taking into account bioavailability and free vitamin D may be preferable, especially when evidence is contradictory, as in obese children. In order to assess bioavailablity and free vitamin D, usin...

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Autores principales:	Gülin Karacan Küçükali, Özlem Gülbahar, Şervan Özalkak, Hasan Dağlı, Serdar Ceylaner, Zehra Aycan, Şenay Savaş Erdeve
Formato:	article
Lenguaje:	EN
Publicado:	Galenos Yayincilik 2021
Materias:	25 hydroxyvitamin d bioavailable vitamin d free vitamin d vitamin d binding protein polymorphism obesity Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/2b2c1df34c954ebda53425e068c22c6d
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spelling	oai:doaj.org-article:2b2c1df34c954ebda53425e068c22c6d2021-11-26T06:10:16ZIs Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?1308-57271308-573510.4274/jcrpe.galenos.2020.2021.0230https://doaj.org/article/2b2c1df34c954ebda53425e068c22c6d2021-12-01T00:00:00Z http://www.jcrpe.org/archives/archive-detail/article-preview/s-bioavailable-vitamin-d-better-than-total-vitamin/47422 https://doaj.org/toc/1308-5727https://doaj.org/toc/1308-5735Objective:Free hormones are biologically more active in target tissues. Thus, measurement of vitamin D taking into account bioavailability and free vitamin D may be preferable, especially when evidence is contradictory, as in obese children. In order to assess bioavailablity and free vitamin D, using a previously reported formula, vitamin D-binding protein (VDBP) level was measured and VDBP polymorphisms were also evaluated because of variations in binding affinity.Methods:Eighty-four obese and 78 healthy children were included. Anthropometry, calcium, phosphorus, alkaline-phosphatase, parathyroid hormone (PTH), 25 hydroxyvitamin D [25(OH)D], bioavailable-free vitamin D, and VDBP concentration and polymorphism were evaluated in the whole group.Results:Obese girls had significantly higher PTH than normal weight girls (p=0.001). Regardless of gender, obese children had significantly higher concentrations of VDBP (p=0.008) and PTH (p=0.002). When samples taken in winter were analyzed, PTH and VDBP were found to be higher and bioavailable and free vitamin D lower in the obese group. There was no difference in terms of total vitamin D between groups during the winter season.Conclusion:While total, free, and bioavailable vitamin D in the obese group was similar to the control group in autumn, free and bioavailable vitamin D in the winter was lower in the obese than the control group. In addition, PTH was higher in the obese group in both autumn and winter. Therefore, more research is needed to evaluate the variability of free and bioavailable vitamin D according to body habitus, season and the effect any differences may have.Gülin Karacan KüçükaliÖzlem GülbaharŞervan ÖzalkakHasan DağlıSerdar CeylanerZehra AycanŞenay Savaş ErdeveGalenos Yayincilikarticle25 hydroxyvitamin dbioavailable vitamin dfree vitamin dvitamin d binding proteinpolymorphismobesityPediatricsRJ1-570Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENJCRPE, Vol 13, Iss 4, Pp 391-399 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	25 hydroxyvitamin d bioavailable vitamin d free vitamin d vitamin d binding protein polymorphism obesity Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	25 hydroxyvitamin d bioavailable vitamin d free vitamin d vitamin d binding protein polymorphism obesity Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Gülin Karacan Küçükali Özlem Gülbahar Şervan Özalkak Hasan Dağlı Serdar Ceylaner Zehra Aycan Şenay Savaş Erdeve Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
description	Objective:Free hormones are biologically more active in target tissues. Thus, measurement of vitamin D taking into account bioavailability and free vitamin D may be preferable, especially when evidence is contradictory, as in obese children. In order to assess bioavailablity and free vitamin D, using a previously reported formula, vitamin D-binding protein (VDBP) level was measured and VDBP polymorphisms were also evaluated because of variations in binding affinity.Methods:Eighty-four obese and 78 healthy children were included. Anthropometry, calcium, phosphorus, alkaline-phosphatase, parathyroid hormone (PTH), 25 hydroxyvitamin D [25(OH)D], bioavailable-free vitamin D, and VDBP concentration and polymorphism were evaluated in the whole group.Results:Obese girls had significantly higher PTH than normal weight girls (p=0.001). Regardless of gender, obese children had significantly higher concentrations of VDBP (p=0.008) and PTH (p=0.002). When samples taken in winter were analyzed, PTH and VDBP were found to be higher and bioavailable and free vitamin D lower in the obese group. There was no difference in terms of total vitamin D between groups during the winter season.Conclusion:While total, free, and bioavailable vitamin D in the obese group was similar to the control group in autumn, free and bioavailable vitamin D in the winter was lower in the obese than the control group. In addition, PTH was higher in the obese group in both autumn and winter. Therefore, more research is needed to evaluate the variability of free and bioavailable vitamin D according to body habitus, season and the effect any differences may have.
format	article
author	Gülin Karacan Küçükali Özlem Gülbahar Şervan Özalkak Hasan Dağlı Serdar Ceylaner Zehra Aycan Şenay Savaş Erdeve
author_facet	Gülin Karacan Küçükali Özlem Gülbahar Şervan Özalkak Hasan Dağlı Serdar Ceylaner Zehra Aycan Şenay Savaş Erdeve
author_sort	Gülin Karacan Küçükali
title	Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
title_short	Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
title_full	Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
title_fullStr	Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
title_full_unstemmed	Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
title_sort	is bioavailable vitamin d better than total vitamin d to evaluate vitamin d status in obese children?
publisher	Galenos Yayincilik
publishDate	2021
url	https://doaj.org/article/2b2c1df34c954ebda53425e068c22c6d
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Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?

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