Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection

Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection

Can Zhu,1 Yuning Liu,2 Haiying Wu1 1Department of Obstetrics and Gynecology, Henan Provincial People’s Hospital, Zhengzhou City, Henan Province, 450003, People’s Republic of China; 2Department of Neonatal Intensive Care Unit, Henan Provincial People’s Hospital, Zhengzhou City, Henan Province, 450003...

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Autores principales: Zhu C, Liu Y, Wu H
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
gestational diabetes mellitus
circactr2
adverse events
Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/2b2cd173e7904b649afec7f2f290f65e
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spelling oai:doaj.org-article:2b2cd173e7904b649afec7f2f290f65e2021-11-30T18:50:36ZOverexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection1178-7007https://doaj.org/article/2b2cd173e7904b649afec7f2f290f65e2021-11-01T00:00:00Zhttps://www.dovepress.com/overexpression-of-circactr2-in-gestational-diabetes-mellitus-predicts--peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Can Zhu,1 Yuning Liu,2 Haiying Wu1 1Department of Obstetrics and Gynecology, Henan Provincial People’s Hospital, Zhengzhou City, Henan Province, 450003, People’s Republic of China; 2Department of Neonatal Intensive Care Unit, Henan Provincial People’s Hospital, Zhengzhou City, Henan Province, 450003, People’s Republic of ChinaCorrespondence: Haiying WuDepartment of Obstetrics and Gynecology, Henan Provincial People’s Hospital, No. 7 Weiwu Road, Jinshui District, Zhengzhou City, Henan Province, 450003, People’s Republic of ChinaEmail haiyingwuhenan@163.comBackground: CircRNA actin-related protein 2 homolog (circACTR2) has been reported to participate in high glucose-induced disorders, while its role in gestational diabetes mellitus (GDM) is unknown. This study analyzed the expression pattern of circACTR2 in GDM and evaluated its predictive value for GDM and its adverse events.Methods: C\ircACTR2 expression in plasma of 200 pregnant females with a gestational age of about 1 month was analyzed once per month using RT-qPCR. The development of GDM was monitored until delivery. Adverse events, including premature delivery, miscarriage, intrauterine distress, intrauterine death, fetal malformation, intrauterine infection, hypertension, and macrosomia, were recorded.Results: During the follow-up, a total of 70 patients were diagnosed with GDM. The 70 GDM patients showed significantly higher plasma circACTR2 levels compared to the remaining 130 pregnant females. With the median plasma circACTR2 level in the first month as the cutoff value, the 200 patients were divided into the high and low circACTR2 level groups, and their GDM-free curves were plotted and compared. Patients in high circACTR2 level group showed a higher incidence of GDM. Moreover, among the 70 patients diagnosed with GDM, high circACTR2 levels were also closely correlated with higher rates of premature delivery, miscarriage, intrauterine death, fetal malformation, intrauterine infection, and hypertension, but not with macrosomia and intrauterine distress.Conclusion: CircACTR2 is overexpressed in GDM. The increased plasma circACTR2 levels in pregnant women predict GDM, and higher plasma circACTR2 levels in GDM patients predict multiple adverse events.Keywords: gestational diabetes mellitus, circACTR2, adverse eventsZhu CLiu YWu HDove Medical Pressarticlegestational diabetes mellituscircactr2adverse eventsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4655-4660 (2021)
institution DOAJ
collection DOAJ
language EN
topic gestational diabetes mellitus
circactr2
adverse events
Specialties of internal medicine
RC581-951
spellingShingle gestational diabetes mellitus
circactr2
adverse events
Specialties of internal medicine
RC581-951
Zhu C
Liu Y
Wu H
Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection
description Can Zhu,1 Yuning Liu,2 Haiying Wu1 1Department of Obstetrics and Gynecology, Henan Provincial People’s Hospital, Zhengzhou City, Henan Province, 450003, People’s Republic of China; 2Department of Neonatal Intensive Care Unit, Henan Provincial People’s Hospital, Zhengzhou City, Henan Province, 450003, People’s Republic of ChinaCorrespondence: Haiying WuDepartment of Obstetrics and Gynecology, Henan Provincial People’s Hospital, No. 7 Weiwu Road, Jinshui District, Zhengzhou City, Henan Province, 450003, People’s Republic of ChinaEmail haiyingwuhenan@163.comBackground: CircRNA actin-related protein 2 homolog (circACTR2) has been reported to participate in high glucose-induced disorders, while its role in gestational diabetes mellitus (GDM) is unknown. This study analyzed the expression pattern of circACTR2 in GDM and evaluated its predictive value for GDM and its adverse events.Methods: C\ircACTR2 expression in plasma of 200 pregnant females with a gestational age of about 1 month was analyzed once per month using RT-qPCR. The development of GDM was monitored until delivery. Adverse events, including premature delivery, miscarriage, intrauterine distress, intrauterine death, fetal malformation, intrauterine infection, hypertension, and macrosomia, were recorded.Results: During the follow-up, a total of 70 patients were diagnosed with GDM. The 70 GDM patients showed significantly higher plasma circACTR2 levels compared to the remaining 130 pregnant females. With the median plasma circACTR2 level in the first month as the cutoff value, the 200 patients were divided into the high and low circACTR2 level groups, and their GDM-free curves were plotted and compared. Patients in high circACTR2 level group showed a higher incidence of GDM. Moreover, among the 70 patients diagnosed with GDM, high circACTR2 levels were also closely correlated with higher rates of premature delivery, miscarriage, intrauterine death, fetal malformation, intrauterine infection, and hypertension, but not with macrosomia and intrauterine distress.Conclusion: CircACTR2 is overexpressed in GDM. The increased plasma circACTR2 levels in pregnant women predict GDM, and higher plasma circACTR2 levels in GDM patients predict multiple adverse events.Keywords: gestational diabetes mellitus, circACTR2, adverse events
format article
author Zhu C
Liu Y
Wu H
author_facet Zhu C
Liu Y
Wu H
author_sort Zhu C
title Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection
title_short Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection
title_full Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection
title_fullStr Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection
title_full_unstemmed Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection
title_sort overexpression of circactr2 in gestational diabetes mellitus predicts intrauterine death, fetal malformation, and intrauterine infection
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/2b2cd173e7904b649afec7f2f290f65e
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AT liuy overexpressionofcircactr2ingestationaldiabetesmellituspredictsintrauterinedeathfetalmalformationandintrauterineinfection
AT wuh overexpressionofcircactr2ingestationaldiabetesmellituspredictsintrauterinedeathfetalmalformationandintrauterineinfection
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