A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm

A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm

Cells in the developing embryo interpret WNT signalling with context-dependence, but the mechanism decoding these cues is unclear. Here, the authors show that combinatorial TALE/HOX activity destabilizes nucleosomes at WNT-responsive regions to activate paraxial mesodermal genes.

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Autores principales: Luca Mariani, Xiaogang Guo, Niels Alvaro Menezes, Anna Maria Drozd, Selgin Deniz Çakal, Qinhu Wang, Elisabetta Ferretti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2b36749acf3440a7ac30e19fa93d159a
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spelling oai:doaj.org-article:2b36749acf3440a7ac30e19fa93d159a2021-12-02T19:02:28ZA TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm10.1038/s41467-021-25370-42041-1723https://doaj.org/article/2b36749acf3440a7ac30e19fa93d159a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25370-4https://doaj.org/toc/2041-1723Cells in the developing embryo interpret WNT signalling with context-dependence, but the mechanism decoding these cues is unclear. Here, the authors show that combinatorial TALE/HOX activity destabilizes nucleosomes at WNT-responsive regions to activate paraxial mesodermal genes.Luca MarianiXiaogang GuoNiels Alvaro MenezesAnna Maria DrozdSelgin Deniz ÇakalQinhu WangElisabetta FerrettiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Luca Mariani
Xiaogang Guo
Niels Alvaro Menezes
Anna Maria Drozd
Selgin Deniz Çakal
Qinhu Wang
Elisabetta Ferretti
A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm
description Cells in the developing embryo interpret WNT signalling with context-dependence, but the mechanism decoding these cues is unclear. Here, the authors show that combinatorial TALE/HOX activity destabilizes nucleosomes at WNT-responsive regions to activate paraxial mesodermal genes.
format article
author Luca Mariani
Xiaogang Guo
Niels Alvaro Menezes
Anna Maria Drozd
Selgin Deniz Çakal
Qinhu Wang
Elisabetta Ferretti
author_facet Luca Mariani
Xiaogang Guo
Niels Alvaro Menezes
Anna Maria Drozd
Selgin Deniz Çakal
Qinhu Wang
Elisabetta Ferretti
author_sort Luca Mariani
title A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm
title_short A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm
title_full A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm
title_fullStr A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm
title_full_unstemmed A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm
title_sort tale/hox code unlocks wnt signalling response towards paraxial mesoderm
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2b36749acf3440a7ac30e19fa93d159a
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