A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm

A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm

Cells in the developing embryo interpret WNT signalling with context-dependence, but the mechanism decoding these cues is unclear. Here, the authors show that combinatorial TALE/HOX activity destabilizes nucleosomes at WNT-responsive regions to activate paraxial mesodermal genes.

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Autores principales: Luca Mariani, Xiaogang Guo, Niels Alvaro Menezes, Anna Maria Drozd, Selgin Deniz Çakal, Qinhu Wang, Elisabetta Ferretti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/2b36749acf3440a7ac30e19fa93d159a
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