Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue

Yen-Ho Lai, Chih-Sheng Chiang, Tzu-Hsun Kao, San-Yuan Chen Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan, Republic of China Introduction: Deep penetration of large-sized drug nanocarriers into tumors is important to improve the efficacy of tumor t...

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Autores principales:	Lai Y, Chiang C, Kao TH, Chen S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Amphiphilic gelatin Nanocarriers Controlled release Deep tumor penetration. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2b38c4de798147b8a1b3ad45aed94035
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spelling	oai:doaj.org-article:2b38c4de798147b8a1b3ad45aed940352021-12-02T07:59:41ZDual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue1178-2013https://doaj.org/article/2b38c4de798147b8a1b3ad45aed940352018-05-01T00:00:00Zhttps://www.dovepress.com/dual-drug-nanomedicine-with-hydrophilic-f127-modified-magnetic-nanocar-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yen-Ho Lai, Chih-Sheng Chiang, Tzu-Hsun Kao, San-Yuan Chen Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan, Republic of China Introduction: Deep penetration of large-sized drug nanocarriers into tumors is important to improve the efficacy of tumor therapy. Methods: In this study, we developed a size-changeable “Trojan Horse” nanocarrier (THNC) composed of paclitaxel (PTX)-loaded Greek soldiers (GSs; ~20 nm) assembled in an amphiphilic gelatin matrix with hydrophilic losartan (LST) added. Results: With amphiphilic gelatin matrix cleavage by matrix metalloproteinase-2, LST showed fast release of up to 60% accumulated drug at 6 h, but a slow release kinetic (~20%) was detected in the PTX from the GSs, indicating that THNCs enable controllable release of LST and PTX drugs for penetration into the tumor tissue. The in vitro cell viability in a 3D tumor spheroid model indicated that the PTX-loaded GSs liberated from THNCs showed deeper penetration as well as higher cytotoxicity, reducing a tumor spheroid to half its original size and collapsing the structure of the tumor microenvironment. Conclusion: The results demonstrate that the THNCs with controlled drug release and deep penetration of magnetic GSs show great potential for cancer therapy. Keywords: amphiphilic gelatin, nanocarriers, controlled release, deep tumor penetrationLai YChiang CKao THChen SDove Medical PressarticleAmphiphilic gelatinNanocarriersControlled releaseDeep tumor penetration.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3011-3026 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amphiphilic gelatin Nanocarriers Controlled release Deep tumor penetration. Medicine (General) R5-920
spellingShingle	Amphiphilic gelatin Nanocarriers Controlled release Deep tumor penetration. Medicine (General) R5-920 Lai Y Chiang C Kao TH Chen S Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
description	Yen-Ho Lai, Chih-Sheng Chiang, Tzu-Hsun Kao, San-Yuan Chen Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan, Republic of China Introduction: Deep penetration of large-sized drug nanocarriers into tumors is important to improve the efficacy of tumor therapy. Methods: In this study, we developed a size-changeable “Trojan Horse” nanocarrier (THNC) composed of paclitaxel (PTX)-loaded Greek soldiers (GSs; ~20 nm) assembled in an amphiphilic gelatin matrix with hydrophilic losartan (LST) added. Results: With amphiphilic gelatin matrix cleavage by matrix metalloproteinase-2, LST showed fast release of up to 60% accumulated drug at 6 h, but a slow release kinetic (~20%) was detected in the PTX from the GSs, indicating that THNCs enable controllable release of LST and PTX drugs for penetration into the tumor tissue. The in vitro cell viability in a 3D tumor spheroid model indicated that the PTX-loaded GSs liberated from THNCs showed deeper penetration as well as higher cytotoxicity, reducing a tumor spheroid to half its original size and collapsing the structure of the tumor microenvironment. Conclusion: The results demonstrate that the THNCs with controlled drug release and deep penetration of magnetic GSs show great potential for cancer therapy. Keywords: amphiphilic gelatin, nanocarriers, controlled release, deep tumor penetration
format	article
author	Lai Y Chiang C Kao TH Chen S
author_facet	Lai Y Chiang C Kao TH Chen S
author_sort	Lai Y
title	Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
title_short	Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
title_full	Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
title_fullStr	Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
title_full_unstemmed	Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
title_sort	dual-drug nanomedicine with hydrophilic f127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/2b38c4de798147b8a1b3ad45aed94035
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Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue

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