Septic arthritis significance: A path toward awareness

Septic arthritis is considered the fastest joint destructive disease and a medical emergency. The most common etiological agents are bacteria; Staphylococcus aureus is the main cause of infection. The etiological agent and the host immune response might determine the clinical presentation and the ev...

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Autores principales:	Jorge A. González-Chapa, Víctor M. Peña-Martínez, José F. Vilchez-Cavazos, Nils Haustedt, Adrián G. Rosas-Taraco
Formato:	article
Lenguaje:	EN ES
Publicado:	Permanyer 2021
Materias:	Septic arthritis. Pathogenesis. Joint destruction. Immune response. Morbidities. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2b39c1eaa2184e2cb4ebd661f77109c1
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spelling	oai:doaj.org-article:2b39c1eaa2184e2cb4ebd661f77109c12021-11-04T01:12:40ZSeptic arthritis significance: A path toward awareness10.24875/RMU.210000161665-57962530-0709https://doaj.org/article/2b39c1eaa2184e2cb4ebd661f77109c12021-04-01T00:00:00Zhttps://www.medicinauniversitaria.org/frame_esp.php?id=128https://doaj.org/toc/1665-5796https://doaj.org/toc/2530-0709Septic arthritis is considered the fastest joint destructive disease and a medical emergency. The most common etiological agents are bacteria; Staphylococcus aureus is the main cause of infection. The etiological agent and the host immune response might determine the clinical presentation and the evolution of the disease. Depending on these factors, septic arthritis might be responsible for many complications, including even death. Understanding the immunopathogenesis responsible for the clinical presentation and creating awareness of its importance may help in the medical education, research approaches, and attention of physicians treating this disease. Evidence indicates that bacteria-specific factors such as adhesins, amino acids, toxins, and superantigens are responsible for joint colonization. However, a dual role with a “double-edged sword effect” of the immune system might be responsible for septic arthritis’s severe consequences. Due to immune system redundancy, there might not be a specific component responsible for the disastrous complications. However, cells as neutrophils, macrophages, T helper cells, and their cytokines might be playing an important role. Physical complications have been well studied. However, little research has been done regarding the possible psychological effects on these patients due to the morbidities, which clearly affect the outcome of the patients. This report aims to review the available literature on joint infections focusing on the most common etiological agents, the immune response, and the impact this disease can create in the patients. Jorge A. González-ChapaVíctor M. Peña-MartínezJosé F. Vilchez-CavazosNils HaustedtAdrián G. Rosas-TaracoPermanyerarticleSeptic arthritis. Pathogenesis. Joint destruction. Immune response. Morbidities.Medicine (General)R5-920ENESMedicina Universitaria, Vol 23, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN ES
topic	Septic arthritis. Pathogenesis. Joint destruction. Immune response. Morbidities. Medicine (General) R5-920
spellingShingle	Septic arthritis. Pathogenesis. Joint destruction. Immune response. Morbidities. Medicine (General) R5-920 Jorge A. González-Chapa Víctor M. Peña-Martínez José F. Vilchez-Cavazos Nils Haustedt Adrián G. Rosas-Taraco Septic arthritis significance: A path toward awareness
description	Septic arthritis is considered the fastest joint destructive disease and a medical emergency. The most common etiological agents are bacteria; Staphylococcus aureus is the main cause of infection. The etiological agent and the host immune response might determine the clinical presentation and the evolution of the disease. Depending on these factors, septic arthritis might be responsible for many complications, including even death. Understanding the immunopathogenesis responsible for the clinical presentation and creating awareness of its importance may help in the medical education, research approaches, and attention of physicians treating this disease. Evidence indicates that bacteria-specific factors such as adhesins, amino acids, toxins, and superantigens are responsible for joint colonization. However, a dual role with a “double-edged sword effect” of the immune system might be responsible for septic arthritis’s severe consequences. Due to immune system redundancy, there might not be a specific component responsible for the disastrous complications. However, cells as neutrophils, macrophages, T helper cells, and their cytokines might be playing an important role. Physical complications have been well studied. However, little research has been done regarding the possible psychological effects on these patients due to the morbidities, which clearly affect the outcome of the patients. This report aims to review the available literature on joint infections focusing on the most common etiological agents, the immune response, and the impact this disease can create in the patients.
format	article
author	Jorge A. González-Chapa Víctor M. Peña-Martínez José F. Vilchez-Cavazos Nils Haustedt Adrián G. Rosas-Taraco
author_facet	Jorge A. González-Chapa Víctor M. Peña-Martínez José F. Vilchez-Cavazos Nils Haustedt Adrián G. Rosas-Taraco
author_sort	Jorge A. González-Chapa
title	Septic arthritis significance: A path toward awareness
title_short	Septic arthritis significance: A path toward awareness
title_full	Septic arthritis significance: A path toward awareness
title_fullStr	Septic arthritis significance: A path toward awareness
title_full_unstemmed	Septic arthritis significance: A path toward awareness
title_sort	septic arthritis significance: a path toward awareness
publisher	Permanyer
publishDate	2021
url	https://doaj.org/article/2b39c1eaa2184e2cb4ebd661f77109c1
work_keys_str_mv	AT jorgeagonzalezchapa septicarthritissignificanceapathtowardawareness AT victormpenamartinez septicarthritissignificanceapathtowardawareness AT josefvilchezcavazos septicarthritissignificanceapathtowardawareness AT nilshaustedt septicarthritissignificanceapathtowardawareness AT adriangrosastaraco septicarthritissignificanceapathtowardawareness
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Septic arthritis significance: A path toward awareness

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