Identification of recurrent USP48 and BRAF mutations in Cushing’s disease
In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutat...
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Nature Portfolio
2018
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oai:doaj.org-article:2b3bf5b0c1aa40f1ad4cc48e49ee5bed2021-12-02T17:33:02ZIdentification of recurrent USP48 and BRAF mutations in Cushing’s disease10.1038/s41467-018-05275-52041-1723https://doaj.org/article/2b3bf5b0c1aa40f1ad4cc48e49ee5bed2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05275-5https://doaj.org/toc/2041-1723In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas.Jianhua ChenXuemin JianSiyu DengZengyi MaXuefei ShouYue ShenQilin ZhangZhijian SongZhiqiang LiHong PengCheng PengMin ChenCheng LuoDan ZhaoZhao YeMing ShenYichao ZhangJuan ZhouAamir FahiraYongfei WangShiqi LiZhaoyun ZhangHongying YeYiming LiJiawei ShenHong ChenFeng TangZhenwei YaoZhifeng ShiChunjui ChenLu XieYe WangChaowei FuYing MaoLiangfu ZhouDaming GaoHai YanYao ZhaoChuanxin HuangYongyong ShiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
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Science Q Jianhua Chen Xuemin Jian Siyu Deng Zengyi Ma Xuefei Shou Yue Shen Qilin Zhang Zhijian Song Zhiqiang Li Hong Peng Cheng Peng Min Chen Cheng Luo Dan Zhao Zhao Ye Ming Shen Yichao Zhang Juan Zhou Aamir Fahira Yongfei Wang Shiqi Li Zhaoyun Zhang Hongying Ye Yiming Li Jiawei Shen Hong Chen Feng Tang Zhenwei Yao Zhifeng Shi Chunjui Chen Lu Xie Ye Wang Chaowei Fu Ying Mao Liangfu Zhou Daming Gao Hai Yan Yao Zhao Chuanxin Huang Yongyong Shi Identification of recurrent USP48 and BRAF mutations in Cushing’s disease |
| description |
In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas. |
| format |
article |
| author |
Jianhua Chen Xuemin Jian Siyu Deng Zengyi Ma Xuefei Shou Yue Shen Qilin Zhang Zhijian Song Zhiqiang Li Hong Peng Cheng Peng Min Chen Cheng Luo Dan Zhao Zhao Ye Ming Shen Yichao Zhang Juan Zhou Aamir Fahira Yongfei Wang Shiqi Li Zhaoyun Zhang Hongying Ye Yiming Li Jiawei Shen Hong Chen Feng Tang Zhenwei Yao Zhifeng Shi Chunjui Chen Lu Xie Ye Wang Chaowei Fu Ying Mao Liangfu Zhou Daming Gao Hai Yan Yao Zhao Chuanxin Huang Yongyong Shi |
| author_facet |
Jianhua Chen Xuemin Jian Siyu Deng Zengyi Ma Xuefei Shou Yue Shen Qilin Zhang Zhijian Song Zhiqiang Li Hong Peng Cheng Peng Min Chen Cheng Luo Dan Zhao Zhao Ye Ming Shen Yichao Zhang Juan Zhou Aamir Fahira Yongfei Wang Shiqi Li Zhaoyun Zhang Hongying Ye Yiming Li Jiawei Shen Hong Chen Feng Tang Zhenwei Yao Zhifeng Shi Chunjui Chen Lu Xie Ye Wang Chaowei Fu Ying Mao Liangfu Zhou Daming Gao Hai Yan Yao Zhao Chuanxin Huang Yongyong Shi |
| author_sort |
Jianhua Chen |
| title |
Identification of recurrent USP48 and BRAF mutations in Cushing’s disease |
| title_short |
Identification of recurrent USP48 and BRAF mutations in Cushing’s disease |
| title_full |
Identification of recurrent USP48 and BRAF mutations in Cushing’s disease |
| title_fullStr |
Identification of recurrent USP48 and BRAF mutations in Cushing’s disease |
| title_full_unstemmed |
Identification of recurrent USP48 and BRAF mutations in Cushing’s disease |
| title_sort |
identification of recurrent usp48 and braf mutations in cushing’s disease |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/2b3bf5b0c1aa40f1ad4cc48e49ee5bed |
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