Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome

Omar A Amin,1 Saleh M Abouzeid,2 Siham A Ali,3 Bashir A Amin,4 Khaled A Alswat51Department of Orthopedic, Al Noor Specialist Hospital, Makkah, Saudi Arabia; 2Department of Rheumatology, Al Azhar University, Cairo, Egypt; 3Department of Neurology, Banha University, Banha, Egypt; 4Department of Medici...

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Autores principales:	Amin OA, Abouzeid SM, Ali SA, Amin BA, Alswat KA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	fibromyalgia vitamin D serotonin Saudi Arabia Taif Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2b3d30fb9efa481a91d9ca0358344e12
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spelling	oai:doaj.org-article:2b3d30fb9efa481a91d9ca0358344e122021-12-02T06:09:55ZClinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome1178-2021https://doaj.org/article/2b3d30fb9efa481a91d9ca0358344e122019-05-01T00:00:00Zhttps://www.dovepress.com/clinical-association-of-vitamin-d-and-serotonin-levels-among-patients--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Omar A Amin,1 Saleh M Abouzeid,2 Siham A Ali,3 Bashir A Amin,4 Khaled A Alswat51Department of Orthopedic, Al Noor Specialist Hospital, Makkah, Saudi Arabia; 2Department of Rheumatology, Al Azhar University, Cairo, Egypt; 3Department of Neurology, Banha University, Banha, Egypt; 4Department of Medicine, Taif University, School of Medicine, Taif, Saudi Arabia; 5Department of Medicine and Endocrinology, Taif University School of Medicine, Taif, Saudi ArabiaObjective: Fibromyalgia syndrome (FMS) is a chronic disorder associated with severe pain. According to the National Fibromyalgia Association, the prevalence of FMS is between 3% and 6% in the general population, with about 90% of the patients being women. The primary goal of this study was to evaluate the relationship between vitamin D and serotonin levels and FMS severity.Methods: Forty participants with fibromyalgia (mean age: 37.8±9.5 years) were included and had their medical history taken, a physical examination, and laboratory testing in the Rheumatology Department at Al-Ameen Hospital in Taif, Saudi Arabia. The revised Fibromyalgia Impact Questionnaire (FIQR) was used to determine the FMS severity.Results: The results showed that 42.5% of the patients were considered to have mild/moderate fibromyalgia, with the remainder having severe/extreme fibromyalgia. The latter were more likely to have lower serotonin levels. The results showed a significant dose-dependent negative relationship between the serotonin levels and FIQR scores (P=0.002). However, no significant correlations were found between the vitamin D levels and FIQR scores (P=0.112).Conclusion: The findings of this study show that the improved health of FMS patients is associated with normal serotonin levels.Keywords: fibromyalgia, vitamin D, serotonin, Saudi Arabia, TaifAmin OAAbouzeid SMAli SAAmin BAAlswat KADove Medical Pressarticlefibromyalgiavitamin DserotoninSaudi ArabiaTaifNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1421-1426 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibromyalgia vitamin D serotonin Saudi Arabia Taif Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	fibromyalgia vitamin D serotonin Saudi Arabia Taif Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Amin OA Abouzeid SM Ali SA Amin BA Alswat KA Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome
description	Omar A Amin,1 Saleh M Abouzeid,2 Siham A Ali,3 Bashir A Amin,4 Khaled A Alswat51Department of Orthopedic, Al Noor Specialist Hospital, Makkah, Saudi Arabia; 2Department of Rheumatology, Al Azhar University, Cairo, Egypt; 3Department of Neurology, Banha University, Banha, Egypt; 4Department of Medicine, Taif University, School of Medicine, Taif, Saudi Arabia; 5Department of Medicine and Endocrinology, Taif University School of Medicine, Taif, Saudi ArabiaObjective: Fibromyalgia syndrome (FMS) is a chronic disorder associated with severe pain. According to the National Fibromyalgia Association, the prevalence of FMS is between 3% and 6% in the general population, with about 90% of the patients being women. The primary goal of this study was to evaluate the relationship between vitamin D and serotonin levels and FMS severity.Methods: Forty participants with fibromyalgia (mean age: 37.8±9.5 years) were included and had their medical history taken, a physical examination, and laboratory testing in the Rheumatology Department at Al-Ameen Hospital in Taif, Saudi Arabia. The revised Fibromyalgia Impact Questionnaire (FIQR) was used to determine the FMS severity.Results: The results showed that 42.5% of the patients were considered to have mild/moderate fibromyalgia, with the remainder having severe/extreme fibromyalgia. The latter were more likely to have lower serotonin levels. The results showed a significant dose-dependent negative relationship between the serotonin levels and FIQR scores (P=0.002). However, no significant correlations were found between the vitamin D levels and FIQR scores (P=0.112).Conclusion: The findings of this study show that the improved health of FMS patients is associated with normal serotonin levels.Keywords: fibromyalgia, vitamin D, serotonin, Saudi Arabia, Taif
format	article
author	Amin OA Abouzeid SM Ali SA Amin BA Alswat KA
author_facet	Amin OA Abouzeid SM Ali SA Amin BA Alswat KA
author_sort	Amin OA
title	Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome
title_short	Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome
title_full	Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome
title_fullStr	Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome
title_full_unstemmed	Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome
title_sort	clinical association of vitamin d and serotonin levels among patients with fibromyalgia syndrome
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2b3d30fb9efa481a91d9ca0358344e12
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Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome

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