Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity

Efficient tumor antigen uptake by dendritic cells is facilitated by antibody coating of tumor cells. Here, the authors develop an approach based on hapten vaccination and hapten/tumor targeting ligand conjugates that potentiate anti-tumor immunity by generating and redirecting serum antibodies to tu...

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Autores principales:	Brett Schrand, Emily Clark, Agata Levay, Ailem Rabasa Capote, Olivier Martinez, Randall Brenneman, Iris Castro, Eli Gilboa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b3fb79e93c34cee87312bf77ce68f7e
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spelling	oai:doaj.org-article:2b3fb79e93c34cee87312bf77ce68f7e2021-12-02T17:33:17ZHapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity10.1038/s41467-018-05566-x2041-1723https://doaj.org/article/2b3fb79e93c34cee87312bf77ce68f7e2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05566-xhttps://doaj.org/toc/2041-1723Efficient tumor antigen uptake by dendritic cells is facilitated by antibody coating of tumor cells. Here, the authors develop an approach based on hapten vaccination and hapten/tumor targeting ligand conjugates that potentiate anti-tumor immunity by generating and redirecting serum antibodies to tumors.Brett SchrandEmily ClarkAgata LevayAilem Rabasa CapoteOlivier MartinezRandall BrennemanIris CastroEli GilboaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brett Schrand Emily Clark Agata Levay Ailem Rabasa Capote Olivier Martinez Randall Brenneman Iris Castro Eli Gilboa Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
description	Efficient tumor antigen uptake by dendritic cells is facilitated by antibody coating of tumor cells. Here, the authors develop an approach based on hapten vaccination and hapten/tumor targeting ligand conjugates that potentiate anti-tumor immunity by generating and redirecting serum antibodies to tumors.
format	article
author	Brett Schrand Emily Clark Agata Levay Ailem Rabasa Capote Olivier Martinez Randall Brenneman Iris Castro Eli Gilboa
author_facet	Brett Schrand Emily Clark Agata Levay Ailem Rabasa Capote Olivier Martinez Randall Brenneman Iris Castro Eli Gilboa
author_sort	Brett Schrand
title	Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
title_short	Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
title_full	Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
title_fullStr	Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
title_full_unstemmed	Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
title_sort	hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2b3fb79e93c34cee87312bf77ce68f7e
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Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity

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