Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system

Prokaryotic CRISPR-Cas systems provide adaptive immunity against foreign nucleic acids by acquiring short, invader-derived sequences called spacers. Here, Staals et al. analyse millions of such events in a native CRISPR-Cas system, showing that newly acquired spacers provoke additional rounds of spa...

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Autores principales:	Raymond H. J. Staals, Simon A. Jackson, Ambarish Biswas, Stan J. J. Brouns, Chris M. Brown, Peter C. Fineran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b405c24d7584a81b02d85c2c41648d7
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spelling	oai:doaj.org-article:2b405c24d7584a81b02d85c2c41648d72021-12-02T16:49:25ZInterference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system10.1038/ncomms128532041-1723https://doaj.org/article/2b405c24d7584a81b02d85c2c41648d72016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12853https://doaj.org/toc/2041-1723Prokaryotic CRISPR-Cas systems provide adaptive immunity against foreign nucleic acids by acquiring short, invader-derived sequences called spacers. Here, Staals et al. analyse millions of such events in a native CRISPR-Cas system, showing that newly acquired spacers provoke additional rounds of spacer acquisition.Raymond H. J. StaalsSimon A. JacksonAmbarish BiswasStan J. J. BrounsChris M. BrownPeter C. FineranNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raymond H. J. Staals Simon A. Jackson Ambarish Biswas Stan J. J. Brouns Chris M. Brown Peter C. Fineran Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
description	Prokaryotic CRISPR-Cas systems provide adaptive immunity against foreign nucleic acids by acquiring short, invader-derived sequences called spacers. Here, Staals et al. analyse millions of such events in a native CRISPR-Cas system, showing that newly acquired spacers provoke additional rounds of spacer acquisition.
format	article
author	Raymond H. J. Staals Simon A. Jackson Ambarish Biswas Stan J. J. Brouns Chris M. Brown Peter C. Fineran
author_facet	Raymond H. J. Staals Simon A. Jackson Ambarish Biswas Stan J. J. Brouns Chris M. Brown Peter C. Fineran
author_sort	Raymond H. J. Staals
title	Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
title_short	Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
title_full	Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
title_fullStr	Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
title_full_unstemmed	Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
title_sort	interference-driven spacer acquisition is dominant over naive and primed adaptation in a native crispr–cas system
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2b405c24d7584a81b02d85c2c41648d7
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Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system

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