Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
Prokaryotic CRISPR-Cas systems provide adaptive immunity against foreign nucleic acids by acquiring short, invader-derived sequences called spacers. Here, Staals et al. analyse millions of such events in a native CRISPR-Cas system, showing that newly acquired spacers provoke additional rounds of spa...
Saved in:
Main Authors: | Raymond H. J. Staals, Simon A. Jackson, Ambarish Biswas, Stan J. J. Brouns, Chris M. Brown, Peter C. Fineran |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
|
Subjects: | |
Online Access: | https://doaj.org/article/2b405c24d7584a81b02d85c2c41648d7 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
CRISPR interference directs strand specific spacer acquisition.
by: Daan C Swarts, et al.
Published: (2012) -
CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction
by: Bridget N. J. Watson, et al.
Published: (2018) -
Recording mobile DNA in the gut microbiota using an Escherichia coli CRISPR-Cas spacer acquisition platform
by: Christian Munck, et al.
Published: (2020) -
Detection of spacer precursors formed in vivo during primed CRISPR adaptation
by: Anna A. Shiriaeva, et al.
Published: (2019) -
The CRISPR Spacer Space Is Dominated by Sequences from Species-Specific Mobilomes
by: Sergey A. Shmakov, et al.
Published: (2017)