Advances in understanding N-glycosylation structure, function, and regulation in health and disease

N-linked glycosylation is a post-translational modification crucial for membrane protein folding, stability and other cellular functions. Alteration of membrane protein N-glycans is implicated in wide range of pathological conditions including cancer metastasis, chronic inflammatory diseases, and vi...

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Autores principales:	Sally Esmail, Morris F. Manolson
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	N-glycan Immunotherapy Glycoediting Biomarker Cancer Rheumatoid arthritis Cytology QH573-671
Acceso en línea:	https://doaj.org/article/2b42ae9b895c4685aa4a5dd7be8c7d9c
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spelling	oai:doaj.org-article:2b42ae9b895c4685aa4a5dd7be8c7d9c2021-11-26T04:23:46ZAdvances in understanding N-glycosylation structure, function, and regulation in health and disease0171-933510.1016/j.ejcb.2021.151186https://doaj.org/article/2b42ae9b895c4685aa4a5dd7be8c7d9c2021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0171933521000376https://doaj.org/toc/0171-9335N-linked glycosylation is a post-translational modification crucial for membrane protein folding, stability and other cellular functions. Alteration of membrane protein N-glycans is implicated in wide range of pathological conditions including cancer metastasis, chronic inflammatory diseases, and viral pathogenesis. Even though the roles of N-glycans have been studied extensively, our knowledge of their mechanisms remains unclear due to the lack of detailed structural analysis of the N-glycome. Mapping the N-glycome landscape will open new avenues to explore disease mechanisms and identify novel therapeutic targets. This review discusses the diverse structure of N-linked glycans, the function and regulation of N-glycosylation in health and disease, and ends with a focus on recent approaches to target N-glycans in rheumatoid arthritis and cancer metastasis.Sally EsmailMorris F. ManolsonElsevierarticleN-glycanImmunotherapyGlycoeditingBiomarkerCancerRheumatoid arthritisCytologyQH573-671ENEuropean Journal of Cell Biology, Vol 100, Iss 7, Pp 151186- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	N-glycan Immunotherapy Glycoediting Biomarker Cancer Rheumatoid arthritis Cytology QH573-671
spellingShingle	N-glycan Immunotherapy Glycoediting Biomarker Cancer Rheumatoid arthritis Cytology QH573-671 Sally Esmail Morris F. Manolson Advances in understanding N-glycosylation structure, function, and regulation in health and disease
description	N-linked glycosylation is a post-translational modification crucial for membrane protein folding, stability and other cellular functions. Alteration of membrane protein N-glycans is implicated in wide range of pathological conditions including cancer metastasis, chronic inflammatory diseases, and viral pathogenesis. Even though the roles of N-glycans have been studied extensively, our knowledge of their mechanisms remains unclear due to the lack of detailed structural analysis of the N-glycome. Mapping the N-glycome landscape will open new avenues to explore disease mechanisms and identify novel therapeutic targets. This review discusses the diverse structure of N-linked glycans, the function and regulation of N-glycosylation in health and disease, and ends with a focus on recent approaches to target N-glycans in rheumatoid arthritis and cancer metastasis.
format	article
author	Sally Esmail Morris F. Manolson
author_facet	Sally Esmail Morris F. Manolson
author_sort	Sally Esmail
title	Advances in understanding N-glycosylation structure, function, and regulation in health and disease
title_short	Advances in understanding N-glycosylation structure, function, and regulation in health and disease
title_full	Advances in understanding N-glycosylation structure, function, and regulation in health and disease
title_fullStr	Advances in understanding N-glycosylation structure, function, and regulation in health and disease
title_full_unstemmed	Advances in understanding N-glycosylation structure, function, and regulation in health and disease
title_sort	advances in understanding n-glycosylation structure, function, and regulation in health and disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2b42ae9b895c4685aa4a5dd7be8c7d9c
work_keys_str_mv	AT sallyesmail advancesinunderstandingnglycosylationstructurefunctionandregulationinhealthanddisease AT morrisfmanolson advancesinunderstandingnglycosylationstructurefunctionandregulationinhealthanddisease
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Advances in understanding N-glycosylation structure, function, and regulation in health and disease

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