Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors

Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying GABA(A)R with alpha5 subunit, and that this inhib...

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Autores principales:	Jan M. Schulz, Frederic Knoflach, Maria-Clemencia Hernandez, Josef Bischofberger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b44f2781de8400fa51141e60c25aa5b
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spelling	oai:doaj.org-article:2b44f2781de8400fa51141e60c25aa5b2021-12-02T17:31:47ZDendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors10.1038/s41467-018-06004-82041-1723https://doaj.org/article/2b44f2781de8400fa51141e60c25aa5b2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06004-8https://doaj.org/toc/2041-1723Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying GABA(A)R with alpha5 subunit, and that this inhibition with slow gating kinetics matches voltage and time-dependent activation of synaptic NMDARs, thereby controlling the generation of dendritic NMDA spikes.Jan M. SchulzFrederic KnoflachMaria-Clemencia HernandezJosef BischofbergerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jan M. Schulz Frederic Knoflach Maria-Clemencia Hernandez Josef Bischofberger Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
description	Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying GABA(A)R with alpha5 subunit, and that this inhibition with slow gating kinetics matches voltage and time-dependent activation of synaptic NMDARs, thereby controlling the generation of dendritic NMDA spikes.
format	article
author	Jan M. Schulz Frederic Knoflach Maria-Clemencia Hernandez Josef Bischofberger
author_facet	Jan M. Schulz Frederic Knoflach Maria-Clemencia Hernandez Josef Bischofberger
author_sort	Jan M. Schulz
title	Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_short	Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_full	Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_fullStr	Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_full_unstemmed	Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors
title_sort	dendrite-targeting interneurons control synaptic nmda-receptor activation via nonlinear α5-gabaa receptors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2b44f2781de8400fa51141e60c25aa5b
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Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors

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