The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects

Hui Hua Chang,1–4 Wei Hung Chang,5 Mei Hung Chi,5 Yi Chin Peng,1 Chih-Chun Huang,5 Yen Kuang Yang,5–7 Po See Chen5,6 1Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2School of Pharmacy, College of M...

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Autores principales:	Chang HH, Chang WH, Chi MH, Peng YC, Huang CC, Yang YK, Chen PS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	glucose insulin oxytocin oxtr polymorphism Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2b470e1a22754090b9a4c43891f25b7d
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spelling	oai:doaj.org-article:2b470e1a22754090b9a4c43891f25b7d2021-12-02T03:36:34ZThe OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects1178-7007https://doaj.org/article/2b470e1a22754090b9a4c43891f25b7d2019-12-01T00:00:00Zhttps://www.dovepress.com/the-oxtr-polymorphism-stratified-the-correlation-of-oxytocin-and-gluco-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Hui Hua Chang,1–4 Wei Hung Chang,5 Mei Hung Chi,5 Yi Chin Peng,1 Chih-Chun Huang,5 Yen Kuang Yang,5–7 Po See Chen5,6 1Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Department of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Department of Pharmacy, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan; 5Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 6Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 7Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, TaiwanCorrespondence: Po See ChenDepartment of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, North District, Tainan 70403, TaiwanTel +886-6-2353535 ext. 5189Fax +886-6-2759259Email chenps@mail.ncku.edu.twObjective: Previous animal studies have shown that the oxytocin system might affect glucose homeostasis through the hypothalamus–pituitary–adrenal (HPA) axis and peripheral organs. Moreover, whether the effect is stratified by the polymorphism of oxytocin receptor gene (OXTR) remains unclear.Methods: In this study, we recruited 89 non-diabetic participants. Their plasma oxytocin and serum insulin profiles were obtained, and the polymorphism of OXTR rs53576 was genotyped.Results: There were significant correlations between the oxytocin level and fasting glucose level (r = –0.29, P <0.01), insulin level (r = –0.26, P = 0.01), and homeostasis model assessment-estimated insulin resistance (HOMA-IR) (r = –0.25, P = 0.01), when adjusted for age, gender, and body mass index (BMI). When further considering the stratification effects of OXTR variation, we found that the oxytocin level was significantly correlated with the fasting glucose level (r = –0.25, P = 0.04), insulin level (r = –0.35, P = 0.03), and HOMA-IR (r = –0.35, P < 0.01) in subjects with the OXTR A allele (n = 75) after adjustment for age, gender, and BMI. In addition, the oxytocin level in those with the GG genotype of OXTR was significantly negatively correlated with the leptin level (n = 14, r = –0.66, P = 0.02).Conclusion: The results demonstrated that the polymorphism of OXTR plays an important role in individual differences in the correlation of oxytocin and glucose homeostasis in non-diabetic subjects.Keywords: glucose, insulin, oxytocin, OXTR, polymorphismChang HHChang WHChi MHPeng YCHuang CCYang YKChen PSDove Medical PressarticleglucoseinsulinoxytocinoxtrpolymorphismSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2707-2713 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	glucose insulin oxytocin oxtr polymorphism Specialties of internal medicine RC581-951
spellingShingle	glucose insulin oxytocin oxtr polymorphism Specialties of internal medicine RC581-951 Chang HH Chang WH Chi MH Peng YC Huang CC Yang YK Chen PS The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects
description	Hui Hua Chang,1–4 Wei Hung Chang,5 Mei Hung Chi,5 Yi Chin Peng,1 Chih-Chun Huang,5 Yen Kuang Yang,5–7 Po See Chen5,6 1Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Department of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Department of Pharmacy, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan; 5Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 6Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 7Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, TaiwanCorrespondence: Po See ChenDepartment of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, North District, Tainan 70403, TaiwanTel +886-6-2353535 ext. 5189Fax +886-6-2759259Email chenps@mail.ncku.edu.twObjective: Previous animal studies have shown that the oxytocin system might affect glucose homeostasis through the hypothalamus–pituitary–adrenal (HPA) axis and peripheral organs. Moreover, whether the effect is stratified by the polymorphism of oxytocin receptor gene (OXTR) remains unclear.Methods: In this study, we recruited 89 non-diabetic participants. Their plasma oxytocin and serum insulin profiles were obtained, and the polymorphism of OXTR rs53576 was genotyped.Results: There were significant correlations between the oxytocin level and fasting glucose level (r = –0.29, P <0.01), insulin level (r = –0.26, P = 0.01), and homeostasis model assessment-estimated insulin resistance (HOMA-IR) (r = –0.25, P = 0.01), when adjusted for age, gender, and body mass index (BMI). When further considering the stratification effects of OXTR variation, we found that the oxytocin level was significantly correlated with the fasting glucose level (r = –0.25, P = 0.04), insulin level (r = –0.35, P = 0.03), and HOMA-IR (r = –0.35, P < 0.01) in subjects with the OXTR A allele (n = 75) after adjustment for age, gender, and BMI. In addition, the oxytocin level in those with the GG genotype of OXTR was significantly negatively correlated with the leptin level (n = 14, r = –0.66, P = 0.02).Conclusion: The results demonstrated that the polymorphism of OXTR plays an important role in individual differences in the correlation of oxytocin and glucose homeostasis in non-diabetic subjects.Keywords: glucose, insulin, oxytocin, OXTR, polymorphism
format	article
author	Chang HH Chang WH Chi MH Peng YC Huang CC Yang YK Chen PS
author_facet	Chang HH Chang WH Chi MH Peng YC Huang CC Yang YK Chen PS
author_sort	Chang HH
title	The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects
title_short	The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects
title_full	The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects
title_fullStr	The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects
title_full_unstemmed	The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects
title_sort	oxtr polymorphism stratified the correlation of oxytocin and glucose homeostasis in non-diabetic subjects
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2b470e1a22754090b9a4c43891f25b7d
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The OXTR Polymorphism Stratified the Correlation of Oxytocin and Glucose Homeostasis in Non-Diabetic Subjects

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