Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

In mammalian female germ cells, parent-specific epigenetic marks are erased and the X chromosome reactivated before entry into meiosis. Here, by combining parental haplotype reconstruction with single-cell transcriptomics of human female embryonic germ cells, the authors demonstrate that epigenetic...

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Autores principales:	Ábel Vértesy, Wibowo Arindrarto, Matthias S. Roost, Björn Reinius, Vanessa Torrens-Juaneda, Monika Bialecka, Ioannis Moustakas, Yavuz Ariyurek, Ewart Kuijk, Hailiang Mei, Rickard Sandberg, Alexander van Oudenaarden, Susana M. Chuva de Sousa Lopes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b4ac2ed364b4f8a93b6e4cd64a219b7
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spelling	oai:doaj.org-article:2b4ac2ed364b4f8a93b6e4cd64a219b72021-12-02T14:38:52ZParental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells10.1038/s41467-018-04215-72041-1723https://doaj.org/article/2b4ac2ed364b4f8a93b6e4cd64a219b72018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04215-7https://doaj.org/toc/2041-1723In mammalian female germ cells, parent-specific epigenetic marks are erased and the X chromosome reactivated before entry into meiosis. Here, by combining parental haplotype reconstruction with single-cell transcriptomics of human female embryonic germ cells, the authors demonstrate that epigenetic reprogramming occurs in a heterogeneous fashion and during a broad time window up to week 14.Ábel VértesyWibowo ArindrartoMatthias S. RoostBjörn ReiniusVanessa Torrens-JuanedaMonika BialeckaIoannis MoustakasYavuz AriyurekEwart KuijkHailiang MeiRickard SandbergAlexander van OudenaardenSusana M. Chuva de Sousa LopesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ábel Vértesy Wibowo Arindrarto Matthias S. Roost Björn Reinius Vanessa Torrens-Juaneda Monika Bialecka Ioannis Moustakas Yavuz Ariyurek Ewart Kuijk Hailiang Mei Rickard Sandberg Alexander van Oudenaarden Susana M. Chuva de Sousa Lopes Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
description	In mammalian female germ cells, parent-specific epigenetic marks are erased and the X chromosome reactivated before entry into meiosis. Here, by combining parental haplotype reconstruction with single-cell transcriptomics of human female embryonic germ cells, the authors demonstrate that epigenetic reprogramming occurs in a heterogeneous fashion and during a broad time window up to week 14.
format	article
author	Ábel Vértesy Wibowo Arindrarto Matthias S. Roost Björn Reinius Vanessa Torrens-Juaneda Monika Bialecka Ioannis Moustakas Yavuz Ariyurek Ewart Kuijk Hailiang Mei Rickard Sandberg Alexander van Oudenaarden Susana M. Chuva de Sousa Lopes
author_facet	Ábel Vértesy Wibowo Arindrarto Matthias S. Roost Björn Reinius Vanessa Torrens-Juaneda Monika Bialecka Ioannis Moustakas Yavuz Ariyurek Ewart Kuijk Hailiang Mei Rickard Sandberg Alexander van Oudenaarden Susana M. Chuva de Sousa Lopes
author_sort	Ábel Vértesy
title	Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
title_short	Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
title_full	Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
title_fullStr	Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
title_full_unstemmed	Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
title_sort	parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2b4ac2ed364b4f8a93b6e4cd64a219b7
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Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

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