Perioperative and postoperative risk factors for corneal graft failure

Alice L Yu,1 Michaela Kaiser,1 Markus Schaumberger,1 Elisabeth Messmer,1 Daniel Kook,1 Ulrich Welge-Lussen2 1Department of Ophthalmology, Ludwig-Maximilians-University, Munich, 2Department of Ophthalmology, Friedrich-Alexander-University, Erlangen, Germany Purpose: In this study, we assessed the...

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Autores principales:	Yu AL, Kaiser M, Schaumberger M, Messmer E, Kook D, Welge-Lussen U
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2b4bd9d5a65745cf8fa27168ccb20708
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spelling	oai:doaj.org-article:2b4bd9d5a65745cf8fa27168ccb207082021-12-02T02:08:08ZPerioperative and postoperative risk factors for corneal graft failure1177-5483https://doaj.org/article/2b4bd9d5a65745cf8fa27168ccb207082014-08-01T00:00:00Zhttp://www.dovepress.com/perioperative-and-postoperative-risk-factors-for-corneal-graft-failure-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Alice L Yu,1 Michaela Kaiser,1 Markus Schaumberger,1 Elisabeth Messmer,1 Daniel Kook,1 Ulrich Welge-Lussen2 1Department of Ophthalmology, Ludwig-Maximilians-University, Munich, 2Department of Ophthalmology, Friedrich-Alexander-University, Erlangen, Germany Purpose: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival.Patients and methods: The medical records of 377 patients who underwent a penetrating keratoplasty between 2001 and 2011 were reviewed. Organ-cultured corneal tissue was obtained from the eye bank of Ludwig-Maximilians-University. Perioperative and postoperative risk factors for graft failure were evaluated by univariate and multivariate analyses.Results: The 5-year overall survival rate of penetrating keratoplasties was 68%. Graft failure occurred in 26% of patients. High-risk keratoplasties, such as repeat penetrating keratoplasties and emergency penetrating keratoplasties, as well as postoperative conditions, such as glaucoma, retinal surgery, suture problems, persistent epithelial defect, infectious keratitis, and graft rejection, were significantly associated with graft failure in the multivariate analyses.Conclusion: This study showed a similar graft-survival rate as demonstrated in previous studies. In addition, a number of perioperative and postoperative risk factors were identified in this specific patient population. Keywords: penetrating keratoplasty, graft failure, risk factor, cornea bankYu ALKaiser MSchaumberger MMessmer EKook DWelge-Lussen UDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1641-1647 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yu AL Kaiser M Schaumberger M Messmer E Kook D Welge-Lussen U Perioperative and postoperative risk factors for corneal graft failure
description	Alice L Yu,1 Michaela Kaiser,1 Markus Schaumberger,1 Elisabeth Messmer,1 Daniel Kook,1 Ulrich Welge-Lussen2 1Department of Ophthalmology, Ludwig-Maximilians-University, Munich, 2Department of Ophthalmology, Friedrich-Alexander-University, Erlangen, Germany Purpose: In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival.Patients and methods: The medical records of 377 patients who underwent a penetrating keratoplasty between 2001 and 2011 were reviewed. Organ-cultured corneal tissue was obtained from the eye bank of Ludwig-Maximilians-University. Perioperative and postoperative risk factors for graft failure were evaluated by univariate and multivariate analyses.Results: The 5-year overall survival rate of penetrating keratoplasties was 68%. Graft failure occurred in 26% of patients. High-risk keratoplasties, such as repeat penetrating keratoplasties and emergency penetrating keratoplasties, as well as postoperative conditions, such as glaucoma, retinal surgery, suture problems, persistent epithelial defect, infectious keratitis, and graft rejection, were significantly associated with graft failure in the multivariate analyses.Conclusion: This study showed a similar graft-survival rate as demonstrated in previous studies. In addition, a number of perioperative and postoperative risk factors were identified in this specific patient population. Keywords: penetrating keratoplasty, graft failure, risk factor, cornea bank
format	article
author	Yu AL Kaiser M Schaumberger M Messmer E Kook D Welge-Lussen U
author_facet	Yu AL Kaiser M Schaumberger M Messmer E Kook D Welge-Lussen U
author_sort	Yu AL
title	Perioperative and postoperative risk factors for corneal graft failure
title_short	Perioperative and postoperative risk factors for corneal graft failure
title_full	Perioperative and postoperative risk factors for corneal graft failure
title_fullStr	Perioperative and postoperative risk factors for corneal graft failure
title_full_unstemmed	Perioperative and postoperative risk factors for corneal graft failure
title_sort	perioperative and postoperative risk factors for corneal graft failure
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/2b4bd9d5a65745cf8fa27168ccb20708
work_keys_str_mv	AT yual perioperativeandpostoperativeriskfactorsforcornealgraftfailure AT kaiserm perioperativeandpostoperativeriskfactorsforcornealgraftfailure AT schaumbergerm perioperativeandpostoperativeriskfactorsforcornealgraftfailure AT messmere perioperativeandpostoperativeriskfactorsforcornealgraftfailure AT kookd perioperativeandpostoperativeriskfactorsforcornealgraftfailure AT welgelussenu perioperativeandpostoperativeriskfactorsforcornealgraftfailure
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Perioperative and postoperative risk factors for corneal graft failure

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