Health-related quality of life in ICU survivors—10 years later

Abstract Many Intensive Care (ICU) survivors experience long lasting impairments in physical and psychological health as well as social functioning. The objective of our study was to evaluate these effects up to 10 years after ICU discharge. We performed a long-term prospective cohort study in patie...

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Autores principales:	José G. M. Hofhuis, Augustinus J. P. Schrijvers, Tjard Schermer, Peter E. Spronk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b4f8ec1c5fc43668688dc023b1d21e2
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spelling	oai:doaj.org-article:2b4f8ec1c5fc43668688dc023b1d21e22021-12-02T18:46:55ZHealth-related quality of life in ICU survivors—10 years later10.1038/s41598-021-94637-z2045-2322https://doaj.org/article/2b4f8ec1c5fc43668688dc023b1d21e22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94637-zhttps://doaj.org/toc/2045-2322Abstract Many Intensive Care (ICU) survivors experience long lasting impairments in physical and psychological health as well as social functioning. The objective of our study was to evaluate these effects up to 10 years after ICU discharge. We performed a long-term prospective cohort study in patients admitted for longer than 48 h in a medical-surgical ICU. We evaluated health-related quality of life (HRQOL) before ICU admission using the Short-form-36 (SF-36), at ICU discharge, at hospital discharge and at 1, 2, 5 and 10 years follow up (all by patients). Changes in HRQOL were assessed based on linear mixed modeling. We included a total of 749 patients (from 2000 to 2008). During 10 years 475 (63.4%) patients had died, 125 (16.7%) patients were lost to follow up and 149 (19.9%) patients could be evaluated. The mean scores of four HRQOL dimensions (i.e., physical functioning (p < 0.001; mean 54, SD 32, effect size 0.77, 95% CI [0.54–1.0]), role-physical (p < 0.001; mean 44, SD 47, effect size 0.65, 95% CI [0.41–0.68] general health (p < 0.001; mean 52, SD 27, effect size 0.48; 95% CI 0.25–0.71) and social functioning (p < 0.001; mean 72, SD 32, effect size 0.41, 95% CI [0.19–0.64]) were still lower 10 years after ICU discharge compared with pre-admission levels (n = 149) and with an age reference population. Almost all SF-36 dimensions changed significantly over time from ICU discharge up to 10 years after ICU discharge. Over the 10 year follow up physical functioning of medical-surgical ICU survivors remains impaired compared with their pre-admission values and an age reference population. However, effect sizes showed no significant differences suggesting that surviving patients largely regained their age-specific HRQOL at 10 years.José G. M. HofhuisAugustinus J. P. SchrijversTjard SchermerPeter E. SpronkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José G. M. Hofhuis Augustinus J. P. Schrijvers Tjard Schermer Peter E. Spronk Health-related quality of life in ICU survivors—10 years later
description	Abstract Many Intensive Care (ICU) survivors experience long lasting impairments in physical and psychological health as well as social functioning. The objective of our study was to evaluate these effects up to 10 years after ICU discharge. We performed a long-term prospective cohort study in patients admitted for longer than 48 h in a medical-surgical ICU. We evaluated health-related quality of life (HRQOL) before ICU admission using the Short-form-36 (SF-36), at ICU discharge, at hospital discharge and at 1, 2, 5 and 10 years follow up (all by patients). Changes in HRQOL were assessed based on linear mixed modeling. We included a total of 749 patients (from 2000 to 2008). During 10 years 475 (63.4%) patients had died, 125 (16.7%) patients were lost to follow up and 149 (19.9%) patients could be evaluated. The mean scores of four HRQOL dimensions (i.e., physical functioning (p < 0.001; mean 54, SD 32, effect size 0.77, 95% CI [0.54–1.0]), role-physical (p < 0.001; mean 44, SD 47, effect size 0.65, 95% CI [0.41–0.68] general health (p < 0.001; mean 52, SD 27, effect size 0.48; 95% CI 0.25–0.71) and social functioning (p < 0.001; mean 72, SD 32, effect size 0.41, 95% CI [0.19–0.64]) were still lower 10 years after ICU discharge compared with pre-admission levels (n = 149) and with an age reference population. Almost all SF-36 dimensions changed significantly over time from ICU discharge up to 10 years after ICU discharge. Over the 10 year follow up physical functioning of medical-surgical ICU survivors remains impaired compared with their pre-admission values and an age reference population. However, effect sizes showed no significant differences suggesting that surviving patients largely regained their age-specific HRQOL at 10 years.
format	article
author	José G. M. Hofhuis Augustinus J. P. Schrijvers Tjard Schermer Peter E. Spronk
author_facet	José G. M. Hofhuis Augustinus J. P. Schrijvers Tjard Schermer Peter E. Spronk
author_sort	José G. M. Hofhuis
title	Health-related quality of life in ICU survivors—10 years later
title_short	Health-related quality of life in ICU survivors—10 years later
title_full	Health-related quality of life in ICU survivors—10 years later
title_fullStr	Health-related quality of life in ICU survivors—10 years later
title_full_unstemmed	Health-related quality of life in ICU survivors—10 years later
title_sort	health-related quality of life in icu survivors—10 years later
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2b4f8ec1c5fc43668688dc023b1d21e2
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Health-related quality of life in ICU survivors—10 years later

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