Mitochondria-Shaping Proteins and Chemotherapy

The emergence, in recent decades, of an entirely new area of “Mitochondrial dynamics”, which consists principally of fission and fusion, reflects the recognition that mitochondria play a significant role in human tumorigenesis and response to therapeutics. Proteins that determine mitochondrial dynam...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Longlong Xie, Tiansheng Zhou, Yujun Xie, Ann M. Bode, Ya Cao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Mitochondria-shaping proteins chemotherapy virus energy metabolism targeted drugs Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2b515027fa3042b2ac3959e84e9240a0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2b515027fa3042b2ac3959e84e9240a0
record_format	dspace
spelling	oai:doaj.org-article:2b515027fa3042b2ac3959e84e9240a02021-11-18T08:29:39ZMitochondria-Shaping Proteins and Chemotherapy2234-943X10.3389/fonc.2021.769036https://doaj.org/article/2b515027fa3042b2ac3959e84e9240a02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.769036/fullhttps://doaj.org/toc/2234-943XThe emergence, in recent decades, of an entirely new area of “Mitochondrial dynamics”, which consists principally of fission and fusion, reflects the recognition that mitochondria play a significant role in human tumorigenesis and response to therapeutics. Proteins that determine mitochondrial dynamics are referred to as “shaping proteins”. Marked heterogeneity has been observed in the response of tumor cells to chemotherapy, which is associated with imbalances in mitochondrial dynamics and function leading to adaptive and acquired resistance to chemotherapeutic agents. Therefore, targeting mitochondria-shaping proteins may prove to be a promising approach to treat chemotherapy resistant cancers. In this review, we summarize the alterations of mitochondrial dynamics in chemotherapeutic processing and the antitumor mechanisms by which chemotherapy drugs synergize with mitochondria-shaping proteins. These might shed light on new biomarkers for better prediction of cancer chemosensitivity and contribute to the exploitation of potent therapeutic strategies for the clinical treatment of cancers.Longlong XieLonglong XieLonglong XieTiansheng ZhouYujun XieAnn M. BodeYa CaoYa CaoYa CaoYa CaoYa CaoFrontiers Media S.A.articleMitochondria-shaping proteinschemotherapyvirusenergy metabolismtargeted drugsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mitochondria-shaping proteins chemotherapy virus energy metabolism targeted drugs Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Mitochondria-shaping proteins chemotherapy virus energy metabolism targeted drugs Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Longlong Xie Longlong Xie Longlong Xie Tiansheng Zhou Yujun Xie Ann M. Bode Ya Cao Ya Cao Ya Cao Ya Cao Ya Cao Mitochondria-Shaping Proteins and Chemotherapy
description	The emergence, in recent decades, of an entirely new area of “Mitochondrial dynamics”, which consists principally of fission and fusion, reflects the recognition that mitochondria play a significant role in human tumorigenesis and response to therapeutics. Proteins that determine mitochondrial dynamics are referred to as “shaping proteins”. Marked heterogeneity has been observed in the response of tumor cells to chemotherapy, which is associated with imbalances in mitochondrial dynamics and function leading to adaptive and acquired resistance to chemotherapeutic agents. Therefore, targeting mitochondria-shaping proteins may prove to be a promising approach to treat chemotherapy resistant cancers. In this review, we summarize the alterations of mitochondrial dynamics in chemotherapeutic processing and the antitumor mechanisms by which chemotherapy drugs synergize with mitochondria-shaping proteins. These might shed light on new biomarkers for better prediction of cancer chemosensitivity and contribute to the exploitation of potent therapeutic strategies for the clinical treatment of cancers.
format	article
author	Longlong Xie Longlong Xie Longlong Xie Tiansheng Zhou Yujun Xie Ann M. Bode Ya Cao Ya Cao Ya Cao Ya Cao Ya Cao
author_facet	Longlong Xie Longlong Xie Longlong Xie Tiansheng Zhou Yujun Xie Ann M. Bode Ya Cao Ya Cao Ya Cao Ya Cao Ya Cao
author_sort	Longlong Xie
title	Mitochondria-Shaping Proteins and Chemotherapy
title_short	Mitochondria-Shaping Proteins and Chemotherapy
title_full	Mitochondria-Shaping Proteins and Chemotherapy
title_fullStr	Mitochondria-Shaping Proteins and Chemotherapy
title_full_unstemmed	Mitochondria-Shaping Proteins and Chemotherapy
title_sort	mitochondria-shaping proteins and chemotherapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2b515027fa3042b2ac3959e84e9240a0
work_keys_str_mv	AT longlongxie mitochondriashapingproteinsandchemotherapy AT longlongxie mitochondriashapingproteinsandchemotherapy AT longlongxie mitochondriashapingproteinsandchemotherapy AT tianshengzhou mitochondriashapingproteinsandchemotherapy AT yujunxie mitochondriashapingproteinsandchemotherapy AT annmbode mitochondriashapingproteinsandchemotherapy AT yacao mitochondriashapingproteinsandchemotherapy AT yacao mitochondriashapingproteinsandchemotherapy AT yacao mitochondriashapingproteinsandchemotherapy AT yacao mitochondriashapingproteinsandchemotherapy AT yacao mitochondriashapingproteinsandchemotherapy
_version_	1718421730411675648

Mitochondria-Shaping Proteins and Chemotherapy

Ejemplares similares