B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

B7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling domains and B7-expressing antigen presenting cells...

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Autores principales: Masashi Watanabe, Ying Lu, Michael Breen, Richard J. Hodes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/2b526663f7e1461c91c46d55318b2189
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spelling oai:doaj.org-article:2b526663f7e1461c91c46d55318b21892021-12-02T13:27:23ZB7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms10.1038/s41467-020-20070-x2041-1723https://doaj.org/article/2b526663f7e1461c91c46d55318b21892020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20070-xhttps://doaj.org/toc/2041-1723B7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling domains and B7-expressing antigen presenting cells mediating these two processes.Masashi WatanabeYing LuMichael BreenRichard J. HodesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Masashi Watanabe
Ying Lu
Michael Breen
Richard J. Hodes
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
description B7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling domains and B7-expressing antigen presenting cells mediating these two processes.
format article
author Masashi Watanabe
Ying Lu
Michael Breen
Richard J. Hodes
author_facet Masashi Watanabe
Ying Lu
Michael Breen
Richard J. Hodes
author_sort Masashi Watanabe
title B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_short B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_full B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_fullStr B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_full_unstemmed B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms
title_sort b7-cd28 co-stimulation modulates central tolerance via thymic clonal deletion and treg generation through distinct mechanisms
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2b526663f7e1461c91c46d55318b2189
work_keys_str_mv AT masashiwatanabe b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
AT yinglu b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
AT michaelbreen b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
AT richardjhodes b7cd28costimulationmodulatescentraltoleranceviathymicclonaldeletionandtreggenerationthroughdistinctmechanisms
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