Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence

Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence

In regenerative animals, how cells respond to injury signals inducing senescence is unclear. Here, the authors show that cells from highly regenerative mammals are resistant to ROS-induced cellular senescence, but non-regenerating species exhibit mitochondrial dysfunction/senescence in response to h...

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Autores principales: Sandeep Saxena, Hemendra Vekaria, Patrick G. Sullivan, Ashley W. Seifert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2b52ffc90ec046e889e894b5fa15e618
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spelling oai:doaj.org-article:2b52ffc90ec046e889e894b5fa15e6182021-12-02T14:38:58ZConnective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence10.1038/s41467-019-12398-w2041-1723https://doaj.org/article/2b52ffc90ec046e889e894b5fa15e6182019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12398-whttps://doaj.org/toc/2041-1723In regenerative animals, how cells respond to injury signals inducing senescence is unclear. Here, the authors show that cells from highly regenerative mammals are resistant to ROS-induced cellular senescence, but non-regenerating species exhibit mitochondrial dysfunction/senescence in response to hydrogen peroxide exposure.Sandeep SaxenaHemendra VekariaPatrick G. SullivanAshley W. SeifertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sandeep Saxena
Hemendra Vekaria
Patrick G. Sullivan
Ashley W. Seifert
Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
description In regenerative animals, how cells respond to injury signals inducing senescence is unclear. Here, the authors show that cells from highly regenerative mammals are resistant to ROS-induced cellular senescence, but non-regenerating species exhibit mitochondrial dysfunction/senescence in response to hydrogen peroxide exposure.
format article
author Sandeep Saxena
Hemendra Vekaria
Patrick G. Sullivan
Ashley W. Seifert
author_facet Sandeep Saxena
Hemendra Vekaria
Patrick G. Sullivan
Ashley W. Seifert
author_sort Sandeep Saxena
title Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
title_short Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
title_full Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
title_fullStr Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
title_full_unstemmed Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
title_sort connective tissue fibroblasts from highly regenerative mammals are refractory to ros-induced cellular senescence
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2b52ffc90ec046e889e894b5fa15e618
work_keys_str_mv AT sandeepsaxena connectivetissuefibroblastsfromhighlyregenerativemammalsarerefractorytorosinducedcellularsenescence
AT hemendravekaria connectivetissuefibroblastsfromhighlyregenerativemammalsarerefractorytorosinducedcellularsenescence
AT patrickgsullivan connectivetissuefibroblastsfromhighlyregenerativemammalsarerefractorytorosinducedcellularsenescence
AT ashleywseifert connectivetissuefibroblastsfromhighlyregenerativemammalsarerefractorytorosinducedcellularsenescence
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