Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence

In regenerative animals, how cells respond to injury signals inducing senescence is unclear. Here, the authors show that cells from highly regenerative mammals are resistant to ROS-induced cellular senescence, but non-regenerating species exhibit mitochondrial dysfunction/senescence in response to h...

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Bibliographic Details
Main Authors: Sandeep Saxena, Hemendra Vekaria, Patrick G. Sullivan, Ashley W. Seifert
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/2b52ffc90ec046e889e894b5fa15e618
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