Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery

Abstract The development of a smart microencapsulation system programmed to actively respond to environmental pH change has long been recognized a key technology in pharmaceutical and food sciences. To this end, we developed hollow microparticles (MPs) with self-controlled macropores that respond to...

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Autores principales:	Ankit Kumar, Carlo Montemagno, Hyo-Jick Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b572afb7d1f4c3b8e5846e51cf38ff5
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spelling	oai:doaj.org-article:2b572afb7d1f4c3b8e5846e51cf38ff52021-12-02T11:52:27ZSmart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery10.1038/s41598-017-03259-x2045-2322https://doaj.org/article/2b572afb7d1f4c3b8e5846e51cf38ff52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03259-xhttps://doaj.org/toc/2045-2322Abstract The development of a smart microencapsulation system programmed to actively respond to environmental pH change has long been recognized a key technology in pharmaceutical and food sciences. To this end, we developed hollow microparticles (MPs) with self-controlled macropores that respond to environmental pH change, using an Oil-in-Water emulsion technique, for oral drug delivery. We observed that freeze-drying of MPs induced closure of macropores. The closing/opening behavior of macropores was confirmed by exposing MPs encapsulating different ingredients (sulforhodamine b, fluorescent nanoparticles, and lactase) to simulated gastrointestinal (GI) fluids. MPs maintained their intact, closed pore structure in gastric pH, and subsequent exposure to intestinal pH resulted in pore opening and ingredients release. Further, MPs displayed higher protection (>15 times) than commercial lactase formulation, indicating the protective ability of the system against harsh GI conditions. This study showed development of a hybrid MP system combining the advantages of solid particles and hollow capsules, exhibiting easy solvent-free loading mechanism and smart protection/release of encapsulates through controllable macropores. Ultimately, our MPs system strives to usher a new research area in smart drug delivery systems and advance the current oral drug delivery technology by solving major challenges in targeted delivery of pH-sensitive therapeutics.Ankit KumarCarlo MontemagnoHyo-Jick ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ankit Kumar Carlo Montemagno Hyo-Jick Choi Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
description	Abstract The development of a smart microencapsulation system programmed to actively respond to environmental pH change has long been recognized a key technology in pharmaceutical and food sciences. To this end, we developed hollow microparticles (MPs) with self-controlled macropores that respond to environmental pH change, using an Oil-in-Water emulsion technique, for oral drug delivery. We observed that freeze-drying of MPs induced closure of macropores. The closing/opening behavior of macropores was confirmed by exposing MPs encapsulating different ingredients (sulforhodamine b, fluorescent nanoparticles, and lactase) to simulated gastrointestinal (GI) fluids. MPs maintained their intact, closed pore structure in gastric pH, and subsequent exposure to intestinal pH resulted in pore opening and ingredients release. Further, MPs displayed higher protection (>15 times) than commercial lactase formulation, indicating the protective ability of the system against harsh GI conditions. This study showed development of a hybrid MP system combining the advantages of solid particles and hollow capsules, exhibiting easy solvent-free loading mechanism and smart protection/release of encapsulates through controllable macropores. Ultimately, our MPs system strives to usher a new research area in smart drug delivery systems and advance the current oral drug delivery technology by solving major challenges in targeted delivery of pH-sensitive therapeutics.
format	article
author	Ankit Kumar Carlo Montemagno Hyo-Jick Choi
author_facet	Ankit Kumar Carlo Montemagno Hyo-Jick Choi
author_sort	Ankit Kumar
title	Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
title_short	Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
title_full	Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
title_fullStr	Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
title_full_unstemmed	Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
title_sort	smart microparticles with a ph-responsive macropore for targeted oral drug delivery
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2b572afb7d1f4c3b8e5846e51cf38ff5
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Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery

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