MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice

Rett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous forMecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.

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Autores principales:	Keerthi Krishnan, Billy Y. B. Lau, Gabrielle Ewall, Z. Josh Huang, Stephen D. Shea
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b5895d8e4a14e788bb12e1a4e851f72
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spelling	oai:doaj.org-article:2b5895d8e4a14e788bb12e1a4e851f722021-12-02T15:38:45ZMECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice10.1038/ncomms140772041-1723https://doaj.org/article/2b5895d8e4a14e788bb12e1a4e851f722017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14077https://doaj.org/toc/2041-1723Rett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous forMecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.Keerthi KrishnanBilly Y. B. LauGabrielle EwallZ. Josh HuangStephen D. SheaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keerthi Krishnan Billy Y. B. Lau Gabrielle Ewall Z. Josh Huang Stephen D. Shea MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
description	Rett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous forMecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.
format	article
author	Keerthi Krishnan Billy Y. B. Lau Gabrielle Ewall Z. Josh Huang Stephen D. Shea
author_facet	Keerthi Krishnan Billy Y. B. Lau Gabrielle Ewall Z. Josh Huang Stephen D. Shea
author_sort	Keerthi Krishnan
title	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_short	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_full	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_fullStr	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_full_unstemmed	MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
title_sort	mecp2 regulates cortical plasticity underlying a learned behaviour in adult female mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2b5895d8e4a14e788bb12e1a4e851f72
work_keys_str_mv	AT keerthikrishnan mecp2regulatescorticalplasticityunderlyingalearnedbehaviourinadultfemalemice AT billyyblau mecp2regulatescorticalplasticityunderlyingalearnedbehaviourinadultfemalemice AT gabrielleewall mecp2regulatescorticalplasticityunderlyingalearnedbehaviourinadultfemalemice AT zjoshhuang mecp2regulatescorticalplasticityunderlyingalearnedbehaviourinadultfemalemice AT stephendshea mecp2regulatescorticalplasticityunderlyingalearnedbehaviourinadultfemalemice
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MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice

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