Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy
Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was d...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:2b597ee8a3434985a82d29f25ae2a8132021-11-04T06:20:38ZColorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy1663-981210.3389/fphar.2021.744085https://doaj.org/article/2b597ee8a3434985a82d29f25ae2a8132021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.744085/fullhttps://doaj.org/toc/1663-9812Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients’ characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management.Nicolas KerckhoveNicolas KerckhoveNicolas KerckhoveMarie SelvyCéline LambertCoralie GonneauGabrielle FeydelCaroline PétorinAgnès Vimal-BaguetSergey MelnikovSharif KullabMohamed HebbarOlivier BouchéFlorian SlimanoVincent BourgeoisValérie Lebrun-LyFrédéric ThuillierThibault MazardDavid TavanKheir Eddine BenmammarBrigitte MonangeMohamed RamdaniDenis Péré-VergéFloriane Huet-PenzAhmed BedjaouiFlorent GentyCécile LeyronnasJérôme BusserollesJérôme BusserollesSophie TrévisVincent PinonDenis PezetDavid BalayssacDavid BalayssacFrontiers Media S.A.articlechemotherapy-induced peripheral neuropathyneuropathic paincolorectal canceroxaliplatincluster analysisTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021) |
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chemotherapy-induced peripheral neuropathy neuropathic pain colorectal cancer oxaliplatin cluster analysis Therapeutics. Pharmacology RM1-950 |
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chemotherapy-induced peripheral neuropathy neuropathic pain colorectal cancer oxaliplatin cluster analysis Therapeutics. Pharmacology RM1-950 Nicolas Kerckhove Nicolas Kerckhove Nicolas Kerckhove Marie Selvy Céline Lambert Coralie Gonneau Gabrielle Feydel Caroline Pétorin Agnès Vimal-Baguet Sergey Melnikov Sharif Kullab Mohamed Hebbar Olivier Bouché Florian Slimano Vincent Bourgeois Valérie Lebrun-Ly Frédéric Thuillier Thibault Mazard David Tavan Kheir Eddine Benmammar Brigitte Monange Mohamed Ramdani Denis Péré-Vergé Floriane Huet-Penz Ahmed Bedjaoui Florent Genty Cécile Leyronnas Jérôme Busserolles Jérôme Busserolles Sophie Trévis Vincent Pinon Denis Pezet David Balayssac David Balayssac Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy |
| description |
Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients’ characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management. |
| format |
article |
| author |
Nicolas Kerckhove Nicolas Kerckhove Nicolas Kerckhove Marie Selvy Céline Lambert Coralie Gonneau Gabrielle Feydel Caroline Pétorin Agnès Vimal-Baguet Sergey Melnikov Sharif Kullab Mohamed Hebbar Olivier Bouché Florian Slimano Vincent Bourgeois Valérie Lebrun-Ly Frédéric Thuillier Thibault Mazard David Tavan Kheir Eddine Benmammar Brigitte Monange Mohamed Ramdani Denis Péré-Vergé Floriane Huet-Penz Ahmed Bedjaoui Florent Genty Cécile Leyronnas Jérôme Busserolles Jérôme Busserolles Sophie Trévis Vincent Pinon Denis Pezet David Balayssac David Balayssac |
| author_facet |
Nicolas Kerckhove Nicolas Kerckhove Nicolas Kerckhove Marie Selvy Céline Lambert Coralie Gonneau Gabrielle Feydel Caroline Pétorin Agnès Vimal-Baguet Sergey Melnikov Sharif Kullab Mohamed Hebbar Olivier Bouché Florian Slimano Vincent Bourgeois Valérie Lebrun-Ly Frédéric Thuillier Thibault Mazard David Tavan Kheir Eddine Benmammar Brigitte Monange Mohamed Ramdani Denis Péré-Vergé Floriane Huet-Penz Ahmed Bedjaoui Florent Genty Cécile Leyronnas Jérôme Busserolles Jérôme Busserolles Sophie Trévis Vincent Pinon Denis Pezet David Balayssac David Balayssac |
| author_sort |
Nicolas Kerckhove |
| title |
Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy |
| title_short |
Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy |
| title_full |
Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy |
| title_fullStr |
Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy |
| title_full_unstemmed |
Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy |
| title_sort |
colorectal cancer survivors suffering from sensory chemotherapy-induced peripheral neuropathy are not a homogenous group: secondary analysis of patients’ profiles with oxaliplatin-induced peripheral neuropathy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/2b597ee8a3434985a82d29f25ae2a813 |
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