Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model

Abstract The objective of this study was to evaluate the potential value of ultrasound (US) shear wave elastography (SWE) in assessing the relative change in elastic modulus in colorectal adenocarcinoma xenograft models in vivo and investigate any correlation with histological analysis. We sought to...

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Autores principales:	Eli Elyas, Efthymia Papaevangelou, Erwin J. Alles, Janine T. Erler, Thomas R. Cox, Simon P. Robinson, Jeffrey C. Bamber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b5b5ae4b7ec44cb881df9534cba1f9f
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spelling	oai:doaj.org-article:2b5b5ae4b7ec44cb881df9534cba1f9f2021-12-02T16:06:19ZCorrelation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model10.1038/s41598-017-00144-52045-2322https://doaj.org/article/2b5b5ae4b7ec44cb881df9534cba1f9f2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00144-5https://doaj.org/toc/2045-2322Abstract The objective of this study was to evaluate the potential value of ultrasound (US) shear wave elastography (SWE) in assessing the relative change in elastic modulus in colorectal adenocarcinoma xenograft models in vivo and investigate any correlation with histological analysis. We sought to test whether non-invasive evaluation of tissue stiffness is indicative of pathological tumour changes and can be used to monitor therapeutic efficacy. US-SWE was performed in tumour xenografts in 15 NCr nude immunodeficient mice, which were treated with either the cytotoxic drug, Irinotecan, or saline as control. Ten tumours were imaged 48 hours post-treatment and five tumours were imaged for up to five times after treatment. All tumours were harvested for histological analysis and comparison with elasticity measurements. Elastic (Young's) modulus prior to treatment was correlated with tumour volume (r = 0.37, p = 0.008). Irinotecan administration caused significant delay in the tumour growth (p = 0.02) when compared to control, but no significant difference in elastic modulus was detected. Histological analysis revealed a significant correlation between tumour necrosis and elastic modulus (r = −0.73, p = 0.026). SWE measurement provided complimentary information to other imaging modalities and could indicate potential changes in the mechanical properties of tumours, which in turn could be related to the stages of tumour development.Eli ElyasEfthymia PapaevangelouErwin J. AllesJanine T. ErlerThomas R. CoxSimon P. RobinsonJeffrey C. BamberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eli Elyas Efthymia Papaevangelou Erwin J. Alles Janine T. Erler Thomas R. Cox Simon P. Robinson Jeffrey C. Bamber Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
description	Abstract The objective of this study was to evaluate the potential value of ultrasound (US) shear wave elastography (SWE) in assessing the relative change in elastic modulus in colorectal adenocarcinoma xenograft models in vivo and investigate any correlation with histological analysis. We sought to test whether non-invasive evaluation of tissue stiffness is indicative of pathological tumour changes and can be used to monitor therapeutic efficacy. US-SWE was performed in tumour xenografts in 15 NCr nude immunodeficient mice, which were treated with either the cytotoxic drug, Irinotecan, or saline as control. Ten tumours were imaged 48 hours post-treatment and five tumours were imaged for up to five times after treatment. All tumours were harvested for histological analysis and comparison with elasticity measurements. Elastic (Young's) modulus prior to treatment was correlated with tumour volume (r = 0.37, p = 0.008). Irinotecan administration caused significant delay in the tumour growth (p = 0.02) when compared to control, but no significant difference in elastic modulus was detected. Histological analysis revealed a significant correlation between tumour necrosis and elastic modulus (r = −0.73, p = 0.026). SWE measurement provided complimentary information to other imaging modalities and could indicate potential changes in the mechanical properties of tumours, which in turn could be related to the stages of tumour development.
format	article
author	Eli Elyas Efthymia Papaevangelou Erwin J. Alles Janine T. Erler Thomas R. Cox Simon P. Robinson Jeffrey C. Bamber
author_facet	Eli Elyas Efthymia Papaevangelou Erwin J. Alles Janine T. Erler Thomas R. Cox Simon P. Robinson Jeffrey C. Bamber
author_sort	Eli Elyas
title	Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
title_short	Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
title_full	Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
title_fullStr	Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
title_full_unstemmed	Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
title_sort	correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2b5b5ae4b7ec44cb881df9534cba1f9f
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Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model

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