Pulmonary valve tissue engineering strategies in large animal models.

In the last 25 years, numerous tissue engineered heart valve (TEHV) strategies have been studied in large animal models. To evaluate, qualify and summarize all available publications, we conducted a systematic review and meta-analysis. We identified 80 reports that studied TEHVs of synthetic or natu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M Uiterwijk, D C van der Valk, R van Vliet, I J de Brouwer, C R Hooijmans, J Kluin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b6178f4459e43b5a2c77b63daa2e541
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2b6178f4459e43b5a2c77b63daa2e541
record_format	dspace
spelling	oai:doaj.org-article:2b6178f4459e43b5a2c77b63daa2e5412021-12-02T20:17:21ZPulmonary valve tissue engineering strategies in large animal models.1932-620310.1371/journal.pone.0258046https://doaj.org/article/2b6178f4459e43b5a2c77b63daa2e5412021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258046https://doaj.org/toc/1932-6203In the last 25 years, numerous tissue engineered heart valve (TEHV) strategies have been studied in large animal models. To evaluate, qualify and summarize all available publications, we conducted a systematic review and meta-analysis. We identified 80 reports that studied TEHVs of synthetic or natural scaffolds in pulmonary position (n = 693 animals). We identified substantial heterogeneity in study designs, methods and outcomes. Most importantly, the quality assessment showed poor reporting in randomization and blinding strategies. Meta-analysis showed no differences in mortality and rate of valve regurgitation between different scaffolds or strategies. However, it revealed a higher transvalvular pressure gradient in synthetic scaffolds (11.6 mmHg; 95% CI, [7.31-15.89]) compared to natural scaffolds (4,67 mmHg; 95% CI, [3,94-5.39]; p = 0.003). These results should be interpreted with caution due to lack of a standardized control group, substantial study heterogeneity, and relatively low number of comparable studies in subgroup analyses. Based on this review, the most adequate scaffold model is still undefined. This review endorses that, to move the TEHV field forward and enable reliable comparisons, it is essential to define standardized methods and ways of reporting. This would greatly enhance the value of individual large animal studies.M UiterwijkD C van der ValkR van VlietI J de BrouwerC R HooijmansJ KluinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258046 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M Uiterwijk D C van der Valk R van Vliet I J de Brouwer C R Hooijmans J Kluin Pulmonary valve tissue engineering strategies in large animal models.
description	In the last 25 years, numerous tissue engineered heart valve (TEHV) strategies have been studied in large animal models. To evaluate, qualify and summarize all available publications, we conducted a systematic review and meta-analysis. We identified 80 reports that studied TEHVs of synthetic or natural scaffolds in pulmonary position (n = 693 animals). We identified substantial heterogeneity in study designs, methods and outcomes. Most importantly, the quality assessment showed poor reporting in randomization and blinding strategies. Meta-analysis showed no differences in mortality and rate of valve regurgitation between different scaffolds or strategies. However, it revealed a higher transvalvular pressure gradient in synthetic scaffolds (11.6 mmHg; 95% CI, [7.31-15.89]) compared to natural scaffolds (4,67 mmHg; 95% CI, [3,94-5.39]; p = 0.003). These results should be interpreted with caution due to lack of a standardized control group, substantial study heterogeneity, and relatively low number of comparable studies in subgroup analyses. Based on this review, the most adequate scaffold model is still undefined. This review endorses that, to move the TEHV field forward and enable reliable comparisons, it is essential to define standardized methods and ways of reporting. This would greatly enhance the value of individual large animal studies.
format	article
author	M Uiterwijk D C van der Valk R van Vliet I J de Brouwer C R Hooijmans J Kluin
author_facet	M Uiterwijk D C van der Valk R van Vliet I J de Brouwer C R Hooijmans J Kluin
author_sort	M Uiterwijk
title	Pulmonary valve tissue engineering strategies in large animal models.
title_short	Pulmonary valve tissue engineering strategies in large animal models.
title_full	Pulmonary valve tissue engineering strategies in large animal models.
title_fullStr	Pulmonary valve tissue engineering strategies in large animal models.
title_full_unstemmed	Pulmonary valve tissue engineering strategies in large animal models.
title_sort	pulmonary valve tissue engineering strategies in large animal models.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2b6178f4459e43b5a2c77b63daa2e541
work_keys_str_mv	AT muiterwijk pulmonaryvalvetissueengineeringstrategiesinlargeanimalmodels AT dcvandervalk pulmonaryvalvetissueengineeringstrategiesinlargeanimalmodels AT rvanvliet pulmonaryvalvetissueengineeringstrategiesinlargeanimalmodels AT ijdebrouwer pulmonaryvalvetissueengineeringstrategiesinlargeanimalmodels AT crhooijmans pulmonaryvalvetissueengineeringstrategiesinlargeanimalmodels AT jkluin pulmonaryvalvetissueengineeringstrategiesinlargeanimalmodels
_version_	1718374394959495168

Pulmonary valve tissue engineering strategies in large animal models.

Ejemplares similares