4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

Redirection of the TCA cycle intermediate aconitate to itaconate production has anti-inflammatory effects. Here the authors show that the itaconate derivative 4-octyl-itaconate is anti-inflammatory partly as a result of inhibiting GAPDH enzymatic activity and thereby glycolysis in macrophages.

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Autores principales:	Shan-Ting Liao, Chao Han, Ding-Qiao Xu, Xiao-Wei Fu, Jun-Song Wang, Ling-Yi Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b66b3e7c6704dc1a4818c1e7d684e87
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spelling	oai:doaj.org-article:2b66b3e7c6704dc1a4818c1e7d684e872021-12-02T14:40:19Z4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects10.1038/s41467-019-13078-52041-1723https://doaj.org/article/2b66b3e7c6704dc1a4818c1e7d684e872019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13078-5https://doaj.org/toc/2041-1723Redirection of the TCA cycle intermediate aconitate to itaconate production has anti-inflammatory effects. Here the authors show that the itaconate derivative 4-octyl-itaconate is anti-inflammatory partly as a result of inhibiting GAPDH enzymatic activity and thereby glycolysis in macrophages.Shan-Ting LiaoChao HanDing-Qiao XuXiao-Wei FuJun-Song WangLing-Yi KongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shan-Ting Liao Chao Han Ding-Qiao Xu Xiao-Wei Fu Jun-Song Wang Ling-Yi Kong 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
description	Redirection of the TCA cycle intermediate aconitate to itaconate production has anti-inflammatory effects. Here the authors show that the itaconate derivative 4-octyl-itaconate is anti-inflammatory partly as a result of inhibiting GAPDH enzymatic activity and thereby glycolysis in macrophages.
format	article
author	Shan-Ting Liao Chao Han Ding-Qiao Xu Xiao-Wei Fu Jun-Song Wang Ling-Yi Kong
author_facet	Shan-Ting Liao Chao Han Ding-Qiao Xu Xiao-Wei Fu Jun-Song Wang Ling-Yi Kong
author_sort	Shan-Ting Liao
title	4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
title_short	4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
title_full	4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
title_fullStr	4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
title_full_unstemmed	4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
title_sort	4-octyl itaconate inhibits aerobic glycolysis by targeting gapdh to exert anti-inflammatory effects
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2b66b3e7c6704dc1a4818c1e7d684e87
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4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

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