Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task

Abstract Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk pr...

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Autores principales:	Wha Young Kim, Bo Ram Cho, Myung Ji Kwak, Jeong-Hoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b6703959ad84c7ba849d3e751b29bc3
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spelling	oai:doaj.org-article:2b6703959ad84c7ba849d3e751b29bc32021-12-02T16:08:11ZInteraction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task10.1038/s41598-017-06408-42045-2322https://doaj.org/article/2b6703959ad84c7ba849d3e751b29bc32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06408-4https://doaj.org/toc/2045-2322Abstract Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference in animal models evaluating decision-making. Here, we trained rats, housed in pairs or in isolation, in a touch screen chamber to detect the association between four different light signals on the screen and accompanied reward and punishment outcomes arranged with different schedules. Then, the rats were allowed to freely choose from 4 different light signals. Once animals showed a stabilized pattern of preference (risk-averse or risk-seeking), they were injected with saline or cocaine (a single injection per day for 7 days) followed by 2 weeks of withdrawal. Then, their preference of choice was re-tested in the touch screen chamber while they were cocaine challenged. All rats significantly changed their preference toward more risky choices when they were exposed to and challenged with cocaine, except those in the risk-averse/isolated housing group. These results indicate that the pre-existing trait toward risk and the housing condition interact to affect the quality of decision-making, and cocaine may help to aggravate this process.Wha Young KimBo Ram ChoMyung Ji KwakJeong-Hoon KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wha Young Kim Bo Ram Cho Myung Ji Kwak Jeong-Hoon Kim Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
description	Abstract Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference in animal models evaluating decision-making. Here, we trained rats, housed in pairs or in isolation, in a touch screen chamber to detect the association between four different light signals on the screen and accompanied reward and punishment outcomes arranged with different schedules. Then, the rats were allowed to freely choose from 4 different light signals. Once animals showed a stabilized pattern of preference (risk-averse or risk-seeking), they were injected with saline or cocaine (a single injection per day for 7 days) followed by 2 weeks of withdrawal. Then, their preference of choice was re-tested in the touch screen chamber while they were cocaine challenged. All rats significantly changed their preference toward more risky choices when they were exposed to and challenged with cocaine, except those in the risk-averse/isolated housing group. These results indicate that the pre-existing trait toward risk and the housing condition interact to affect the quality of decision-making, and cocaine may help to aggravate this process.
format	article
author	Wha Young Kim Bo Ram Cho Myung Ji Kwak Jeong-Hoon Kim
author_facet	Wha Young Kim Bo Ram Cho Myung Ji Kwak Jeong-Hoon Kim
author_sort	Wha Young Kim
title	Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_short	Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_full	Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_fullStr	Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_full_unstemmed	Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_sort	interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2b6703959ad84c7ba849d3e751b29bc3
work_keys_str_mv	AT whayoungkim interactionbetweentraitandhousingconditionproducesdifferentialdecisionmakingtowardriskchoiceinaratgamblingtask AT boramcho interactionbetweentraitandhousingconditionproducesdifferentialdecisionmakingtowardriskchoiceinaratgamblingtask AT myungjikwak interactionbetweentraitandhousingconditionproducesdifferentialdecisionmakingtowardriskchoiceinaratgamblingtask AT jeonghoonkim interactionbetweentraitandhousingconditionproducesdifferentialdecisionmakingtowardriskchoiceinaratgamblingtask
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Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task

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