Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy

Background: Oral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP. Methods: A population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy w...

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Autores principales:	Paolo G. Arduino, Alessandro Magliano, Alessio Gambino, Alessandra Macciotta, Mario Carbone, Davide Conrotto, Dora Karimi, Marco Carrozzo, Roberto Broccoletti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lichen planus malignant transformation clinical features treatment outcome HCV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2b6907302b204dea856cd18c5b16b508
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spelling	oai:doaj.org-article:2b6907302b204dea856cd18c5b16b5082021-11-25T17:03:27ZRisk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy10.3390/cancers132257402072-6694https://doaj.org/article/2b6907302b204dea856cd18c5b16b5082021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5740https://doaj.org/toc/2072-6694Background: Oral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP. Methods: A population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy was performed. The primary endpoint of the study was that of the histopathological diagnosis of oral cancer during the follow-up period. Results: The study population comprised 3173 patients. During the follow-up period, 32 men and 50 women developed an oral squamous cell carcinoma (2.58%), with a mean time of 103.61 months after the initial diagnosis of OLP, and 21 patients died because of oral cancer. Almost half of the deceased patients had the last follow-up visit before cancer diagnosis in a period of more than 12 months. Older age, having a red form of OLP and fewer sites of involvement, increased the risk of having cancer, while age and no treatment increased the risk of death. Conclusion: This is the largest group of OLP patients with such a long follow up ever reported. Due to the increased risk of having a malignant transformation, especially in elderly subjects, OLP patients should be regularly followed up, particularly in the Northern Italian population.Paolo G. ArduinoAlessandro MaglianoAlessio GambinoAlessandra MacciottaMario CarboneDavide ConrottoDora KarimiMarco CarrozzoRoberto BroccolettiMDPI AGarticlelichen planusmalignant transformationclinical featurestreatmentoutcomeHCVNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5740, p 5740 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lichen planus malignant transformation clinical features treatment outcome HCV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lichen planus malignant transformation clinical features treatment outcome HCV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Paolo G. Arduino Alessandro Magliano Alessio Gambino Alessandra Macciotta Mario Carbone Davide Conrotto Dora Karimi Marco Carrozzo Roberto Broccoletti Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy
description	Background: Oral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP. Methods: A population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy was performed. The primary endpoint of the study was that of the histopathological diagnosis of oral cancer during the follow-up period. Results: The study population comprised 3173 patients. During the follow-up period, 32 men and 50 women developed an oral squamous cell carcinoma (2.58%), with a mean time of 103.61 months after the initial diagnosis of OLP, and 21 patients died because of oral cancer. Almost half of the deceased patients had the last follow-up visit before cancer diagnosis in a period of more than 12 months. Older age, having a red form of OLP and fewer sites of involvement, increased the risk of having cancer, while age and no treatment increased the risk of death. Conclusion: This is the largest group of OLP patients with such a long follow up ever reported. Due to the increased risk of having a malignant transformation, especially in elderly subjects, OLP patients should be regularly followed up, particularly in the Northern Italian population.
format	article
author	Paolo G. Arduino Alessandro Magliano Alessio Gambino Alessandra Macciotta Mario Carbone Davide Conrotto Dora Karimi Marco Carrozzo Roberto Broccoletti
author_facet	Paolo G. Arduino Alessandro Magliano Alessio Gambino Alessandra Macciotta Mario Carbone Davide Conrotto Dora Karimi Marco Carrozzo Roberto Broccoletti
author_sort	Paolo G. Arduino
title	Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy
title_short	Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy
title_full	Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy
title_fullStr	Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy
title_full_unstemmed	Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy
title_sort	risk of malignant transformation in 3173 subjects with histopathologically confirmed oral lichen planus: a 33-year cohort study in northern italy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2b6907302b204dea856cd18c5b16b508
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Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy

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