Transformation from calcium sulfate to calcium phosphate in biological environment

Abstract The formation of a nano-apatite surface layer is frequently considered a measure of bioactivity, especially for non-phosphate bioceramics. In the present study, strontium-doped calcium sulfate, (Ca,Sr)SO4, was used to verify the feasibility of this measure. The (Ca,Sr)SO4 specimen was prepa...

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Autores principales:	Ying-Cen Chen, Wei-Hsing Tuan, Po-Liang Lai
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	Materials of engineering and construction. Mechanics of materials TA401-492 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/2b6c6afa2f894a32981ee5892297515d
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spelling	oai:doaj.org-article:2b6c6afa2f894a32981ee5892297515d2021-12-05T12:19:15ZTransformation from calcium sulfate to calcium phosphate in biological environment10.1007/s10856-021-06622-70957-45301573-4838https://doaj.org/article/2b6c6afa2f894a32981ee5892297515d2021-12-01T00:00:00Zhttps://doi.org/10.1007/s10856-021-06622-7https://doaj.org/toc/0957-4530https://doaj.org/toc/1573-4838Abstract The formation of a nano-apatite surface layer is frequently considered a measure of bioactivity, especially for non-phosphate bioceramics. In the present study, strontium-doped calcium sulfate, (Ca,Sr)SO4, was used to verify the feasibility of this measure. The (Ca,Sr)SO4 specimen was prepared by mixing 10% SrSO4 by weight with 90% CaSO4·½H2O powder by weight. A solid solution of (Ca,7.6%Sr)SO4 was then produced by heating the powder mixture at 1100 °C for 1 h. The resulting (Ca,Sr)SO4 specimen was readily degradable in phosphate solution. A newly formed surface layer in the form of flakes was formed within one day of specimen immersion in phosphate solution. Structural and microstructure–compositional analyses indicated that the flakes were composed of octacalcium phosphate (OCP) crystals. An amorphous interface containing OCP nanocrystals was found between the newly formed surface layer and the remaining (Ca,Sr)SO4 specimen. The specimen was also implanted into a rat distal femur bone defect. In addition to new bone, fibrous tissue and inflammatory cells were found to interlace the (Ca,Sr)SO4 specimen. The present study indicated that a more comprehensive evaluation is needed to assess the bioactivity of non-phosphate bioceramics. The newly formed surface layer on the (Ca,Sr)SO4 specimen after soaking in phosphate solution for 28 days.Ying-Cen ChenWei-Hsing TuanPo-Liang LaiSpringerarticleMaterials of engineering and construction. Mechanics of materialsTA401-492Medical technologyR855-855.5ENJournal of Materials Science: Materials in Medicine, Vol 32, Iss 12, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Materials of engineering and construction. Mechanics of materials TA401-492 Medical technology R855-855.5
spellingShingle	Materials of engineering and construction. Mechanics of materials TA401-492 Medical technology R855-855.5 Ying-Cen Chen Wei-Hsing Tuan Po-Liang Lai Transformation from calcium sulfate to calcium phosphate in biological environment
description	Abstract The formation of a nano-apatite surface layer is frequently considered a measure of bioactivity, especially for non-phosphate bioceramics. In the present study, strontium-doped calcium sulfate, (Ca,Sr)SO4, was used to verify the feasibility of this measure. The (Ca,Sr)SO4 specimen was prepared by mixing 10% SrSO4 by weight with 90% CaSO4·½H2O powder by weight. A solid solution of (Ca,7.6%Sr)SO4 was then produced by heating the powder mixture at 1100 °C for 1 h. The resulting (Ca,Sr)SO4 specimen was readily degradable in phosphate solution. A newly formed surface layer in the form of flakes was formed within one day of specimen immersion in phosphate solution. Structural and microstructure–compositional analyses indicated that the flakes were composed of octacalcium phosphate (OCP) crystals. An amorphous interface containing OCP nanocrystals was found between the newly formed surface layer and the remaining (Ca,Sr)SO4 specimen. The specimen was also implanted into a rat distal femur bone defect. In addition to new bone, fibrous tissue and inflammatory cells were found to interlace the (Ca,Sr)SO4 specimen. The present study indicated that a more comprehensive evaluation is needed to assess the bioactivity of non-phosphate bioceramics. The newly formed surface layer on the (Ca,Sr)SO4 specimen after soaking in phosphate solution for 28 days.
format	article
author	Ying-Cen Chen Wei-Hsing Tuan Po-Liang Lai
author_facet	Ying-Cen Chen Wei-Hsing Tuan Po-Liang Lai
author_sort	Ying-Cen Chen
title	Transformation from calcium sulfate to calcium phosphate in biological environment
title_short	Transformation from calcium sulfate to calcium phosphate in biological environment
title_full	Transformation from calcium sulfate to calcium phosphate in biological environment
title_fullStr	Transformation from calcium sulfate to calcium phosphate in biological environment
title_full_unstemmed	Transformation from calcium sulfate to calcium phosphate in biological environment
title_sort	transformation from calcium sulfate to calcium phosphate in biological environment
publisher	Springer
publishDate	2021
url	https://doaj.org/article/2b6c6afa2f894a32981ee5892297515d
work_keys_str_mv	AT yingcenchen transformationfromcalciumsulfatetocalciumphosphateinbiologicalenvironment AT weihsingtuan transformationfromcalciumsulfatetocalciumphosphateinbiologicalenvironment AT polianglai transformationfromcalciumsulfatetocalciumphosphateinbiologicalenvironment
_version_	1718372006639960064

Transformation from calcium sulfate to calcium phosphate in biological environment

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