<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat

Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether <span style="font-variant: small-caps;">l</span>-theanine, a major amino acid found in green tea, ameliorates bladde...

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Autores principales:	Kanako Matsuoka, Hidenori Akaihata, Junya Hata, Ryo Tanji, Ruriko Honda-Takinami, Akifumi Onagi, Seiji Hoshi, Tomoyuki Koguchi, Yuichi Sato, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojima
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<span style="font-variant: small-caps">l</span>-theanine chronic sympathetic hyperactivity bladder dysfunction prevention oral administration Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2b71df6b9f5d42908a7009ceffdf67b2
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spelling	oai:doaj.org-article:2b71df6b9f5d42908a7009ceffdf67b22021-11-25T18:20:51Z<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat10.3390/metabo111107782218-1989https://doaj.org/article/2b71df6b9f5d42908a7009ceffdf67b22021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/778https://doaj.org/toc/2218-1989Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether <span style="font-variant: small-caps;">l</span>-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered <span style="font-variant: small-caps;">l</span>-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility.Kanako MatsuokaHidenori AkaihataJunya HataRyo TanjiRuriko Honda-TakinamiAkifumi OnagiSeiji HoshiTomoyuki KoguchiYuichi SatoMasao KataokaSoichiro OgawaYoshiyuki KojimaMDPI AGarticle<span style="font-variant: small-caps">l</span>-theaninechronic sympathetic hyperactivitybladder dysfunctionpreventionoral administrationMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 778, p 778 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<span style="font-variant: small-caps">l</span>-theanine chronic sympathetic hyperactivity bladder dysfunction prevention oral administration Microbiology QR1-502
spellingShingle	<span style="font-variant: small-caps">l</span>-theanine chronic sympathetic hyperactivity bladder dysfunction prevention oral administration Microbiology QR1-502 Kanako Matsuoka Hidenori Akaihata Junya Hata Ryo Tanji Ruriko Honda-Takinami Akifumi Onagi Seiji Hoshi Tomoyuki Koguchi Yuichi Sato Masao Kataoka Soichiro Ogawa Yoshiyuki Kojima <span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
description	Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether <span style="font-variant: small-caps;">l</span>-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR–water and SHR–theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR–theanine than in the SHR–water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR–theanine than in the SHR–water group. Bladder strip contractility was also higher in the SHR–theanine than in the SHR–water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR–theanine than in the SHR–water group. These results suggested that orally administered <span style="font-variant: small-caps;">l</span>-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility.
format	article
author	Kanako Matsuoka Hidenori Akaihata Junya Hata Ryo Tanji Ruriko Honda-Takinami Akifumi Onagi Seiji Hoshi Tomoyuki Koguchi Yuichi Sato Masao Kataoka Soichiro Ogawa Yoshiyuki Kojima
author_facet	Kanako Matsuoka Hidenori Akaihata Junya Hata Ryo Tanji Ruriko Honda-Takinami Akifumi Onagi Seiji Hoshi Tomoyuki Koguchi Yuichi Sato Masao Kataoka Soichiro Ogawa Yoshiyuki Kojima
author_sort	Kanako Matsuoka
title	<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_short	<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_full	<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_fullStr	<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_full_unstemmed	<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat
title_sort	<span style="font-variant: small-caps">l</span>-theanine protects bladder function by suppressing chronic sympathetic hyperactivity in spontaneously hypertensive rat
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2b71df6b9f5d42908a7009ceffdf67b2
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<span style="font-variant: small-caps">l</span>-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat

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