Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer

Transcription factors (TFs) often form distinct networks to regulate transcriptional program during cancer progression. Here the authors show that OCT4 is a common transcriptional factor in two types of advanced PC and as such, OCT4 accelerates a TF complex formation with the FOXA1/AR in castration-...

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Autores principales:	Ken-ichi Takayama, Takeo Kosaka, Takashi Suzuki, Hiroshi Hongo, Mototsugu Oya, Tetsuya Fujimura, Yutaka Suzuki, Satoshi Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b73a811b1d0417eaa5e38130166687b
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spelling	oai:doaj.org-article:2b73a811b1d0417eaa5e38130166687b2021-12-02T17:24:21ZSubtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer10.1038/s41467-021-23974-42041-1723https://doaj.org/article/2b73a811b1d0417eaa5e38130166687b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23974-4https://doaj.org/toc/2041-1723Transcription factors (TFs) often form distinct networks to regulate transcriptional program during cancer progression. Here the authors show that OCT4 is a common transcriptional factor in two types of advanced PC and as such, OCT4 accelerates a TF complex formation with the FOXA1/AR in castration-resistant PC and NRF1 in neuroendocrine PC.Ken-ichi TakayamaTakeo KosakaTakashi SuzukiHiroshi HongoMototsugu OyaTetsuya FujimuraYutaka SuzukiSatoshi InoueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ken-ichi Takayama Takeo Kosaka Takashi Suzuki Hiroshi Hongo Mototsugu Oya Tetsuya Fujimura Yutaka Suzuki Satoshi Inoue Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer
description	Transcription factors (TFs) often form distinct networks to regulate transcriptional program during cancer progression. Here the authors show that OCT4 is a common transcriptional factor in two types of advanced PC and as such, OCT4 accelerates a TF complex formation with the FOXA1/AR in castration-resistant PC and NRF1 in neuroendocrine PC.
format	article
author	Ken-ichi Takayama Takeo Kosaka Takashi Suzuki Hiroshi Hongo Mototsugu Oya Tetsuya Fujimura Yutaka Suzuki Satoshi Inoue
author_facet	Ken-ichi Takayama Takeo Kosaka Takashi Suzuki Hiroshi Hongo Mototsugu Oya Tetsuya Fujimura Yutaka Suzuki Satoshi Inoue
author_sort	Ken-ichi Takayama
title	Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer
title_short	Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer
title_full	Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer
title_fullStr	Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer
title_full_unstemmed	Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer
title_sort	subtype-specific collaborative transcription factor networks are promoted by oct4 in the progression of prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2b73a811b1d0417eaa5e38130166687b
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Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer

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