Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 1–2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katiane Roversi, Natalia Callai-Silva, Karine Roversi, May Griffith, Christos Boutopoulos, Rui Daniel Prediger, Sébastien Talbot
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease pain nociceptor neurons neuro-immunity microbiota dysbiosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2b75063e3eb14437a175729816bf73c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2b75063e3eb14437a175729816bf73c6
record_format	dspace
spelling	oai:doaj.org-article:2b75063e3eb14437a175729816bf73c62021-11-18T07:34:01ZNeuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain1664-322410.3389/fimmu.2021.759679https://doaj.org/article/2b75063e3eb14437a175729816bf73c62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.759679/fullhttps://doaj.org/toc/1664-3224Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 1–2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-brain axis that alters immunity and the inflammatory state and subsequently drives neurodegeneration. There is increasing evidence linking gut dysbiosis to the severity of PD’s motor symptoms as well as to somatosensory hypersensitivities. Altogether, these interdependent features highlight the urgency of reviewing the links between the onset of PD’s non-motor symptoms and gut immunity and whether such interplays drive the progression of PD. This review will shed light on maladaptive neuro-immune crosstalk in the context of gut dysbiosis and will posit that such deleterious interplays lead to PD-induced pain hypersensitivity.Katiane RoversiKatiane RoversiKatiane RoversiKatiane RoversiNatalia Callai-SilvaNatalia Callai-SilvaNatalia Callai-SilvaKarine RoversiMay GriffithMay GriffithChristos BoutopoulosChristos BoutopoulosRui Daniel PredigerSébastien TalbotFrontiers Media S.A.articleParkinson’s diseasepainnociceptor neuronsneuro-immunitymicrobiotadysbiosisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease pain nociceptor neurons neuro-immunity microbiota dysbiosis Immunologic diseases. Allergy RC581-607
spellingShingle	Parkinson’s disease pain nociceptor neurons neuro-immunity microbiota dysbiosis Immunologic diseases. Allergy RC581-607 Katiane Roversi Katiane Roversi Katiane Roversi Katiane Roversi Natalia Callai-Silva Natalia Callai-Silva Natalia Callai-Silva Karine Roversi May Griffith May Griffith Christos Boutopoulos Christos Boutopoulos Rui Daniel Prediger Sébastien Talbot Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
description	Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 1–2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-brain axis that alters immunity and the inflammatory state and subsequently drives neurodegeneration. There is increasing evidence linking gut dysbiosis to the severity of PD’s motor symptoms as well as to somatosensory hypersensitivities. Altogether, these interdependent features highlight the urgency of reviewing the links between the onset of PD’s non-motor symptoms and gut immunity and whether such interplays drive the progression of PD. This review will shed light on maladaptive neuro-immune crosstalk in the context of gut dysbiosis and will posit that such deleterious interplays lead to PD-induced pain hypersensitivity.
format	article
author	Katiane Roversi Katiane Roversi Katiane Roversi Katiane Roversi Natalia Callai-Silva Natalia Callai-Silva Natalia Callai-Silva Karine Roversi May Griffith May Griffith Christos Boutopoulos Christos Boutopoulos Rui Daniel Prediger Sébastien Talbot
author_facet	Katiane Roversi Katiane Roversi Katiane Roversi Katiane Roversi Natalia Callai-Silva Natalia Callai-Silva Natalia Callai-Silva Karine Roversi May Griffith May Griffith Christos Boutopoulos Christos Boutopoulos Rui Daniel Prediger Sébastien Talbot
author_sort	Katiane Roversi
title	Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
title_short	Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
title_full	Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
title_fullStr	Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
title_full_unstemmed	Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain
title_sort	neuro-immunity and gut dysbiosis drive parkinson’s disease-induced pain
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2b75063e3eb14437a175729816bf73c6
work_keys_str_mv	AT katianeroversi neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT katianeroversi neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT katianeroversi neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT katianeroversi neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT nataliacallaisilva neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT nataliacallaisilva neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT nataliacallaisilva neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT karineroversi neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT maygriffith neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT maygriffith neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT christosboutopoulos neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT christosboutopoulos neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT ruidanielprediger neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain AT sebastientalbot neuroimmunityandgutdysbiosisdriveparkinsonsdiseaseinducedpain
_version_	1718423276291620864

Neuro-Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain

Ejemplares similares