In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting. Additionally, they report co-crystal structures of the variants bo...

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Autores principales:	Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2b758208695d4e46949303210404e03c
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spelling	oai:doaj.org-article:2b758208695d4e46949303210404e03c2021-12-02T19:13:48ZIn vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance10.1038/s42003-021-02565-52399-3642https://doaj.org/article/2b758208695d4e46949303210404e03c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02565-5https://doaj.org/toc/2399-3642Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting. Additionally, they report co-crystal structures of the variants bound to the Fc neonatal receptor that allow insights into the binding interactions.Lu ShanNydia Van DykNantaporn HaskinsKimberly M. CookKim L. RosenthalRonit MazorSonia Dragulin-OttoYu JiangHerren WuWilliam F. Dall’AcquaMartin J. BorrokMelissa M. DamschroderVaheh OganesyanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lu Shan Nydia Van Dyk Nantaporn Haskins Kimberly M. Cook Kim L. Rosenthal Ronit Mazor Sonia Dragulin-Otto Yu Jiang Herren Wu William F. Dall’Acqua Martin J. Borrok Melissa M. Damschroder Vaheh Oganesyan In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
description	Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting. Additionally, they report co-crystal structures of the variants bound to the Fc neonatal receptor that allow insights into the binding interactions.
format	article
author	Lu Shan Nydia Van Dyk Nantaporn Haskins Kimberly M. Cook Kim L. Rosenthal Ronit Mazor Sonia Dragulin-Otto Yu Jiang Herren Wu William F. Dall’Acqua Martin J. Borrok Melissa M. Damschroder Vaheh Oganesyan
author_facet	Lu Shan Nydia Van Dyk Nantaporn Haskins Kimberly M. Cook Kim L. Rosenthal Ronit Mazor Sonia Dragulin-Otto Yu Jiang Herren Wu William F. Dall’Acqua Martin J. Borrok Melissa M. Damschroder Vaheh Oganesyan
author_sort	Lu Shan
title	In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
title_short	In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
title_full	In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
title_fullStr	In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
title_full_unstemmed	In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
title_sort	in vivo pharmacokinetic enhancement of monomeric fc and monovalent bispecific designs through structural guidance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2b758208695d4e46949303210404e03c
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In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

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