Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5

Katz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural activity oscillations driving repetitive behaviour.

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Autores principales:	Menachem Katz, Francis Corson, Wolfgang Keil, Anupriya Singhal, Andrea Bae, Yun Lu, Yupu Liang, Shai Shaham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b7596e726bc4d719dfc4d8b1846dd17
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spelling	oai:doaj.org-article:2b7596e726bc4d719dfc4d8b1846dd172021-12-02T16:57:20ZGlutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR510.1038/s41467-019-09581-42041-1723https://doaj.org/article/2b7596e726bc4d719dfc4d8b1846dd172019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09581-4https://doaj.org/toc/2041-1723Katz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural activity oscillations driving repetitive behaviour.Menachem KatzFrancis CorsonWolfgang KeilAnupriya SinghalAndrea BaeYun LuYupu LiangShai ShahamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Menachem Katz Francis Corson Wolfgang Keil Anupriya Singhal Andrea Bae Yun Lu Yupu Liang Shai Shaham Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5
description	Katz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural activity oscillations driving repetitive behaviour.
format	article
author	Menachem Katz Francis Corson Wolfgang Keil Anupriya Singhal Andrea Bae Yun Lu Yupu Liang Shai Shaham
author_facet	Menachem Katz Francis Corson Wolfgang Keil Anupriya Singhal Andrea Bae Yun Lu Yupu Liang Shai Shaham
author_sort	Menachem Katz
title	Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5
title_short	Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5
title_full	Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5
title_fullStr	Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5
title_full_unstemmed	Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5
title_sort	glutamate spillover in c. elegans triggers repetitive behavior through presynaptic activation of mgl-2/mglur5
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2b7596e726bc4d719dfc4d8b1846dd17
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Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5

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