Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing
ObjectiveTo determine the effect of gender of reciprocal chromosomal translocation on blastocyst formation and pregnancy outcome in preimplantation genetic testing, including different parental ages.MethodsThis was a retrospective cohort study that enrolled 1034 couples undergoing preimplantation ge...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2b776ec1a0a04d809ba29c1f15ee9116 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2b776ec1a0a04d809ba29c1f15ee9116 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2b776ec1a0a04d809ba29c1f15ee91162021-11-09T10:15:56ZEffects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing1664-239210.3389/fendo.2021.704299https://doaj.org/article/2b776ec1a0a04d809ba29c1f15ee91162021-07-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.704299/fullhttps://doaj.org/toc/1664-2392ObjectiveTo determine the effect of gender of reciprocal chromosomal translocation on blastocyst formation and pregnancy outcome in preimplantation genetic testing, including different parental ages.MethodsThis was a retrospective cohort study that enrolled 1034 couples undergoing preimplantation genetic testing-structural rearrangement on account of a carrier of reciprocal chromosomal translocation from the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2015 to December 2019. Group A represented 528 couples in which the man was the carrier of reciprocal translocation and group B represented 506 couples in which the woman was the carrier of reciprocal translocation. All patients were divided into two groups according to their age: female age<35 and female age≥35. Furthermore, the differences in blastocyst condition and pregnancy outcome between male and female carriers in each group were further explored according to their father’s age.ResultsThe blastocyst formation rate of group A (55.3%) is higher than that of group B (50%) and the results were statistically significant (P<0.05). The blastocyst formation rate of group A is higher than that of group B, no matter in young maternal age or in advanced maternal age (P<0.05). The blastocyst formation rate in maternal age<35y and paternal age<30y in group A(57.1%) is higher than that of Group B(50%); Similarly, the blastocyst formation rate in maternal age≥35 and paternal age≥38y(66.7%) is higher than that of Group B(33.3%)(all P<0.05). There was no difference in fertilization rate, aeuploidy rate, clinical pregnancy rate, miscarriage rate and live birth rate between Group A and Group B.ConclusionWhen the carrier of reciprocal translocation is male, the blastocyst formation rate is higher than that of female carrier. While there is no significant difference between the two in terms of fertilization rate, aeuploidy rate, clinical pregnancy rate, miscarriage rate and live birth rate.Hui SongHui SongHao ShiHao ShiEn-tong YangEn-tong YangZhi-qin BuZhi-qin BuZi-qi JinZi-qi JinMing-zhu HuoMing-zhu HuoYi-le ZhangYi-le ZhangFrontiers Media S.A.articlebiopsyclinical pregnancy ratematernal agepaternal agepreimplantation genetic testingreciprocal translocationDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
biopsy clinical pregnancy rate maternal age paternal age preimplantation genetic testing reciprocal translocation Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
biopsy clinical pregnancy rate maternal age paternal age preimplantation genetic testing reciprocal translocation Diseases of the endocrine glands. Clinical endocrinology RC648-665 Hui Song Hui Song Hao Shi Hao Shi En-tong Yang En-tong Yang Zhi-qin Bu Zhi-qin Bu Zi-qi Jin Zi-qi Jin Ming-zhu Huo Ming-zhu Huo Yi-le Zhang Yi-le Zhang Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing |
| description |
ObjectiveTo determine the effect of gender of reciprocal chromosomal translocation on blastocyst formation and pregnancy outcome in preimplantation genetic testing, including different parental ages.MethodsThis was a retrospective cohort study that enrolled 1034 couples undergoing preimplantation genetic testing-structural rearrangement on account of a carrier of reciprocal chromosomal translocation from the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2015 to December 2019. Group A represented 528 couples in which the man was the carrier of reciprocal translocation and group B represented 506 couples in which the woman was the carrier of reciprocal translocation. All patients were divided into two groups according to their age: female age<35 and female age≥35. Furthermore, the differences in blastocyst condition and pregnancy outcome between male and female carriers in each group were further explored according to their father’s age.ResultsThe blastocyst formation rate of group A (55.3%) is higher than that of group B (50%) and the results were statistically significant (P<0.05). The blastocyst formation rate of group A is higher than that of group B, no matter in young maternal age or in advanced maternal age (P<0.05). The blastocyst formation rate in maternal age<35y and paternal age<30y in group A(57.1%) is higher than that of Group B(50%); Similarly, the blastocyst formation rate in maternal age≥35 and paternal age≥38y(66.7%) is higher than that of Group B(33.3%)(all P<0.05). There was no difference in fertilization rate, aeuploidy rate, clinical pregnancy rate, miscarriage rate and live birth rate between Group A and Group B.ConclusionWhen the carrier of reciprocal translocation is male, the blastocyst formation rate is higher than that of female carrier. While there is no significant difference between the two in terms of fertilization rate, aeuploidy rate, clinical pregnancy rate, miscarriage rate and live birth rate. |
| format |
article |
| author |
Hui Song Hui Song Hao Shi Hao Shi En-tong Yang En-tong Yang Zhi-qin Bu Zhi-qin Bu Zi-qi Jin Zi-qi Jin Ming-zhu Huo Ming-zhu Huo Yi-le Zhang Yi-le Zhang |
| author_facet |
Hui Song Hui Song Hao Shi Hao Shi En-tong Yang En-tong Yang Zhi-qin Bu Zhi-qin Bu Zi-qi Jin Zi-qi Jin Ming-zhu Huo Ming-zhu Huo Yi-le Zhang Yi-le Zhang |
| author_sort |
Hui Song |
| title |
Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing |
| title_short |
Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing |
| title_full |
Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing |
| title_fullStr |
Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing |
| title_full_unstemmed |
Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing |
| title_sort |
effects of gender of reciprocal chromosomal translocation on blastocyst formation and pregnancy outcome in preimplantation genetic testing |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/2b776ec1a0a04d809ba29c1f15ee9116 |
| work_keys_str_mv |
AT huisong effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT huisong effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT haoshi effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT haoshi effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT entongyang effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT entongyang effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT zhiqinbu effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT zhiqinbu effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT ziqijin effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT ziqijin effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT mingzhuhuo effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT mingzhuhuo effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT yilezhang effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting AT yilezhang effectsofgenderofreciprocalchromosomaltranslocationonblastocystformationandpregnancyoutcomeinpreimplantationgenetictesting |
| _version_ |
1718441093035458560 |