Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease

Abstract Chronic diseases, such as chronic kidney disease (CKD), are frequently accompanied by various comorbidities, including anemia, which is considered a surrogate marker of systemic inflammation. Psoriasis is a chronic inflammatory skin disease prevalent in patients with chronic disease. Psoria...

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Autores principales:	Si-Hyung Lee, Miri Kim, Kyung-Do Han, Ji Hyun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b7daf4388ab495aa47ab558ff0969e0
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spelling	oai:doaj.org-article:2b7daf4388ab495aa47ab558ff0969e02021-12-02T16:17:28ZLow hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease10.1038/s41598-021-94165-w2045-2322https://doaj.org/article/2b7daf4388ab495aa47ab558ff0969e02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94165-whttps://doaj.org/toc/2045-2322Abstract Chronic diseases, such as chronic kidney disease (CKD), are frequently accompanied by various comorbidities, including anemia, which is considered a surrogate marker of systemic inflammation. Psoriasis is a chronic inflammatory skin disease prevalent in patients with chronic disease. Psoriasis risk in patients with CKD, however, especially in patients with low hemoglobin levels, has never been investigated. In this study, we investigated associations between low hemoglobin levels and psoriasis in patients with CKD using data from the National Health Insurance Service of Korea. During a mean follow-up period of 6.16 ± 1.02 years, psoriasis was recorded in 13,803 patients with CKD (2.39% of CKD patients). The cumulative incidence of psoriasis was significantly higher in CKD patients with anemia (hemoglobin levels < 13 g/dL in men and < 12 g/dL in women) than those without. In multivariate-adjusted Cox proportional hazards regression models, the risk of psoriasis was significantly higher in anemic CKD patients than nonanemic CKD patients (hazard ratio [HR] 1.136, 95% CI 1.089–1.185, p < 0.001). Additionally, we noted that the incidence of psoriasis decreased with increasing hemoglobin levels in CKD patients (HR 0.953, 95% CI 0.942–0.965, p < 0.001). Altogether, our findings indicate that low hemoglobin levels are significantly related to psoriasis risk in patients with CKD. Further study is required to elucidate whether low hemoglobin levels have an impact on the development of psoriasis or are merely a surrogate marker of psoriasis risk in patients with CKD.Si-Hyung LeeMiri KimKyung-Do HanJi Hyun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Si-Hyung Lee Miri Kim Kyung-Do Han Ji Hyun Lee Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease
description	Abstract Chronic diseases, such as chronic kidney disease (CKD), are frequently accompanied by various comorbidities, including anemia, which is considered a surrogate marker of systemic inflammation. Psoriasis is a chronic inflammatory skin disease prevalent in patients with chronic disease. Psoriasis risk in patients with CKD, however, especially in patients with low hemoglobin levels, has never been investigated. In this study, we investigated associations between low hemoglobin levels and psoriasis in patients with CKD using data from the National Health Insurance Service of Korea. During a mean follow-up period of 6.16 ± 1.02 years, psoriasis was recorded in 13,803 patients with CKD (2.39% of CKD patients). The cumulative incidence of psoriasis was significantly higher in CKD patients with anemia (hemoglobin levels < 13 g/dL in men and < 12 g/dL in women) than those without. In multivariate-adjusted Cox proportional hazards regression models, the risk of psoriasis was significantly higher in anemic CKD patients than nonanemic CKD patients (hazard ratio [HR] 1.136, 95% CI 1.089–1.185, p < 0.001). Additionally, we noted that the incidence of psoriasis decreased with increasing hemoglobin levels in CKD patients (HR 0.953, 95% CI 0.942–0.965, p < 0.001). Altogether, our findings indicate that low hemoglobin levels are significantly related to psoriasis risk in patients with CKD. Further study is required to elucidate whether low hemoglobin levels have an impact on the development of psoriasis or are merely a surrogate marker of psoriasis risk in patients with CKD.
format	article
author	Si-Hyung Lee Miri Kim Kyung-Do Han Ji Hyun Lee
author_facet	Si-Hyung Lee Miri Kim Kyung-Do Han Ji Hyun Lee
author_sort	Si-Hyung Lee
title	Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease
title_short	Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease
title_full	Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease
title_fullStr	Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease
title_full_unstemmed	Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease
title_sort	low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2b7daf4388ab495aa47ab558ff0969e0
work_keys_str_mv	AT sihyunglee lowhemoglobinlevelsandanincreasedriskofpsoriasisinpatientswithchronickidneydisease AT mirikim lowhemoglobinlevelsandanincreasedriskofpsoriasisinpatientswithchronickidneydisease AT kyungdohan lowhemoglobinlevelsandanincreasedriskofpsoriasisinpatientswithchronickidneydisease AT jihyunlee lowhemoglobinlevelsandanincreasedriskofpsoriasisinpatientswithchronickidneydisease
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Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease

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